ENSMUSG00000070738


Mus musculus

Features
Gene ID: ENSMUSG00000070738
  
Biological name :Dgkd
  
Synonyms : Dgkd / diacylglycerol kinase delta
  
Possible biological names infered from orthology : Q16760
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 87853287
Gene end: 87945180
  
Corresponding Affymetrix probe sets: 10348321 (MoGene1.0st)   1433564_at (Mouse Genome 430 2.0 Array)   1439873_at (Mouse Genome 430 2.0 Array)   1443781_at (Mouse Genome 430 2.0 Array)   1454655_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027517
Ensembl peptide - ENSMUSP00000140070
Ensembl peptide - ENSMUSP00000139658
Ensembl peptide - ENSMUSP00000139626
NCBI entrez gene - 227333     See in Manteia.
MGI - MGI:2138334
RefSeq - XM_017320352
RefSeq - XM_006529471
RefSeq - XM_006529472
RefSeq - XM_006529473
RefSeq - XM_006529474
RefSeq - XM_011247988
RefSeq - NM_177646
RefSeq Peptide - NP_808314
swissprot - A0A087WQ75
swissprot - A0A087WP73
swissprot - A0A087WP49
swissprot - E9PUQ8
Ensembl - ENSMUSG00000070738
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DGKDENSDARG00000113111Danio rerio
 DGKDENSGALG00000001730Gallus gallus
 DGKDENSG00000077044Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dgkh / diacylglycerol kinase eta / Q86XP1*ENSMUSG0000003473160
Dgkk / diacylglycerol kinase kappa / Q5KSL6*ENSMUSG0000006239336
Dgkb / Q6NS52 / Diacylglycerol kinase beta / Q9Y6T7*ENSMUSG0000003609519
Dgkg / Q91WG7 / Diacylglycerol kinase gamma / P49619*ENSMUSG0000002286119
Dgki / diacylglycerol kinase iota isoform 2 / O75912* / diacylglycerol kinase iota*ENSMUSG0000003866518
Dgkz / Q80UP3 / Diacylglycerol kinase zeta / Q13574*ENSMUSG0000004047918
Dgkq / Q6P5E8 / Diacylglycerol kinase theta / P52824*ENSMUSG0000000481517
Dgka / O88673 / Mus musculus diacylglycerol kinase, alpha (Dgka), transcript variant 2, mRNA. / P23743* / diacylglycerol kinase alpha*ENSMUSG0000002535717
Dgke / Q9R1C6 / Diacylglycerol kinase epsilon / P52429*ENSMUSG0000000027615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR001660  Sterile alpha motif domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010033 response to organic substance ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046339 diacylglycerol metabolic process ISO
 biological_processGO:0051260 protein homooligomerization ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISO


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Gfi1tm3(Gfib1)Tmo/Gfi1tm3(Gfib1)Tmo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Gfi1tm3(Gfib1)Tmo/Gfi1tm3(Gfib1)Tmo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Ptprbtm1Gdy/Ptprbtm1Gdy
Genetic Background: involves: 129 * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Ptprbtm1Gdy/Ptprbtm1Gdy
Genetic Background: involves: 129 * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprbtm1Gdy/Ptprbtm1Gdy
Genetic Background: involves: 129 * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gfi1tm3(Gfib1)Tmo/Gfi1tm3(Gfib1)Tmo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gfi1tm3(Gfib1)Tmo/Gfi1tm3(Gfib1)Tmo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gfi1tm3(Gfib1)Tmo/Gfi1tm3(Gfib1)Tmo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Gfi1tm3(Gfib1)Tmo/Gfi1tm3(Gfib1)Tmo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gfi1tm3(Gfib1)Tmo/Gfi1tm3(Gfib1)Tmo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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