ENSG00000065357


Homo sapiens

Features
Gene ID: ENSG00000065357
  
Biological name :DGKA
  
Synonyms : DGKA / diacylglycerol kinase alpha / P23743
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.2
Gene start: 55927319
Gene end: 55954027
  
Corresponding Affymetrix probe sets: 1569428_at (Human Genome U133 Plus 2.0 Array)   203385_at (Human Genome U133 Plus 2.0 Array)   211272_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451743
Ensembl peptide - ENSP00000451518
Ensembl peptide - ENSP00000451814
Ensembl peptide - ENSP00000452353
Ensembl peptide - ENSP00000328405
Ensembl peptide - ENSP00000377703
Ensembl peptide - ENSP00000385792
Ensembl peptide - ENSP00000402307
Ensembl peptide - ENSP00000446515
Ensembl peptide - ENSP00000446605
Ensembl peptide - ENSP00000447050
Ensembl peptide - ENSP00000447460
Ensembl peptide - ENSP00000448565
Ensembl peptide - ENSP00000449178
Ensembl peptide - ENSP00000449923
Ensembl peptide - ENSP00000450359
Ensembl peptide - ENSP00000450608
Ensembl peptide - ENSP00000450977
Ensembl peptide - ENSP00000450999
Ensembl peptide - ENSP00000451266
Ensembl peptide - ENSP00000451330
NCBI entrez gene - 1606     See in Manteia.
OMIM - 125855
RefSeq - XM_017018909
RefSeq - NM_001351033
RefSeq - NM_001351035
RefSeq - NM_001351036
RefSeq - NM_001351037
RefSeq - NM_001351038
RefSeq - NM_001351039
RefSeq - NM_001351040
RefSeq - NM_201444
RefSeq - NM_201445
RefSeq - NM_201554
RefSeq - XM_005268688
RefSeq - XM_005268689
RefSeq - XM_005268690
RefSeq - XM_011537991
RefSeq - XM_011537993
RefSeq - XM_011537995
RefSeq - XM_017018900
RefSeq - XM_017018901
RefSeq - XM_017018902
RefSeq - XM_017018903
RefSeq - XM_017018904
RefSeq - XM_017018905
RefSeq - XM_017018906
RefSeq - XM_017018907
RefSeq - XM_017018908
RefSeq - NM_001345
RefSeq Peptide - NP_001337963
RefSeq Peptide - NP_001337964
RefSeq Peptide - NP_001337965
RefSeq Peptide - NP_001337966
RefSeq Peptide - NP_001337967
RefSeq Peptide - NP_001337968
RefSeq Peptide - NP_001337969
RefSeq Peptide - NP_958852
RefSeq Peptide - NP_958853
RefSeq Peptide - NP_963848
RefSeq Peptide - NP_001336
RefSeq Peptide - NP_001337962
swissprot - A0A024RB23
swissprot - C9JM35
swissprot - F8VNZ9
swissprot - F8VWX8
swissprot - F8W1H7
swissprot - F8W1M3
swissprot - G3V312
swissprot - G3V327
swissprot - G3V4E1
swissprot - G3V4I3
swissprot - H0YJE7
swissprot - H0YJH4
swissprot - P23743
Ensembl - ENSG00000065357
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dgkaaENSDARG00000060626Danio rerio
 dgkabENSDARG00000098175Danio rerio
 DGKAENSGALG00000038110Gallus gallus
 DgkaENSMUSG00000025357Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DGKB / Q9Y6T7 / diacylglycerol kinase betaENSG0000013626760
DGKG / P49619 / diacylglycerol kinase gammaENSG0000005886656
DGKD / Q16760 / diacylglycerol kinase deltaENSG0000007704430
DGKH / Q86XP1 / diacylglycerol kinase etaENSG0000010278029
DGKK / Q5KSL6 / diacylglycerol kinase kappaENSG0000027458828
DGKI / O75912 / diacylglycerol kinase iotaENSG0000015768027
DGKQ / P52824 / diacylglycerol kinase thetaENSG0000014521427
DGKZ / Q13574 / diacylglycerol kinase zetaENSG0000014909127
DGKE / P52429 / diacylglycerol kinase epsilonENSG0000015393325


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal
 IPR018247  EF-Hand 1, calcium-binding site
 IPR029477  Diacylglycerol kinase type I, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006654 phosphatidic acid biosynthetic process IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0046339 diacylglycerol metabolic process IDA
 biological_processGO:0046486 glycerolipid metabolic process IDA
 biological_processGO:0046834 lipid phosphorylation IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr