ENSG00000058866


Homo sapiens

Features
Gene ID: ENSG00000058866
  
Biological name :DGKG
  
Synonyms : DGKG / diacylglycerol kinase gamma / P49619
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q27.3
Gene start: 186105668
Gene end: 186362237
  
Corresponding Affymetrix probe sets: 206395_at (Human Genome U133 Plus 2.0 Array)   242319_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265022
Ensembl peptide - ENSP00000339777
Ensembl peptide - ENSP00000371599
Ensembl peptide - ENSP00000395526
NCBI entrez gene - 1608     See in Manteia.
OMIM - 601854
RefSeq - NM_001080744
RefSeq - NM_001080745
RefSeq - NM_001346
RefSeq Peptide - NP_001074213
RefSeq Peptide - NP_001074214
RefSeq Peptide - NP_001337
swissprot - P49619
swissprot - H7C0L0
Ensembl - ENSG00000058866
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dgkgENSDARG00000062696Danio rerio
 DGKGENSGALG00000005721Gallus gallus
 DgkgENSMUSG00000022861Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DGKB / Q9Y6T7 / diacylglycerol kinase betaENSG0000013626762
DGKA / P23743 / diacylglycerol kinase alphaENSG0000006535752
DGKD / Q16760 / diacylglycerol kinase deltaENSG0000007704428
DGKH / Q86XP1 / diacylglycerol kinase etaENSG0000010278028
DGKZ / Q13574 / diacylglycerol kinase zetaENSG0000014909127
DGKK / Q5KSL6 / diacylglycerol kinase kappaENSG0000027458827
DGKQ / P52824 / diacylglycerol kinase thetaENSG0000014521427
DGKI / O75912 / diacylglycerol kinase iotaENSG0000015768025
DGKE / P52429 / diacylglycerol kinase epsilonENSG0000015393324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal
 IPR018247  EF-Hand 1, calcium-binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029477  Diacylglycerol kinase type I, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046486 glycerolipid metabolic process IDA
 biological_processGO:0046834 lipid phosphorylation IDA
 biological_processGO:0048666 neuron development IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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