ENSG00000274588


Homo sapiens

Features
Gene ID: ENSG00000274588
  
Biological name :DGKK
  
Synonyms : DGKK / diacylglycerol kinase kappa / Q5KSL6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: p11.22
Gene start: 50365409
Gene end: 50470738
  
Corresponding Affymetrix probe sets: 238194_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477515
NCBI entrez gene - 139189     See in Manteia.
OMIM - 300837
RefSeq - NM_001013742
RefSeq - XM_017029268
RefSeq Peptide - NP_001013764
swissprot - Q5KSL6
Ensembl - ENSG00000274588
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DgkkENSMUSG00000062393Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DGKH / Q86XP1 / diacylglycerol kinase etaENSG0000010278037
DGKD / Q16760 / diacylglycerol kinase deltaENSG0000007704437
DGKB / Q9Y6T7 / diacylglycerol kinase betaENSG0000013626717
DGKZ / Q13574 / diacylglycerol kinase zetaENSG0000014909117
DGKG / P49619 / diacylglycerol kinase gammaENSG0000005886617
DGKI / O75912 / diacylglycerol kinase iotaENSG0000015768016
DGKA / P23743 / diacylglycerol kinase alphaENSG0000006535716
DGKQ / P52824 / diacylglycerol kinase thetaENSG0000014521416
DGKE / P52429 / diacylglycerol kinase epsilonENSG0000015393315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000756  Diacylglycerol kinase, accessory domain
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0046339 diacylglycerol metabolic process IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0004143 diacylglycerol kinase activity IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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