ENSMUSG00000000632


Mus musculus

Features
Gene ID: ENSMUSG00000000632
  
Biological name :Sez6
  
Synonyms : Q7TSK2 / Seizure protein 6 / Sez6
  
Possible biological names infered from orthology : Q53EL9 / seizure related 6 homolog
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 77930800
Gene end: 77979048
  
Corresponding Affymetrix probe sets: 10378964 (MoGene1.0st)   1420885_a_at (Mouse Genome 430 2.0 Array)   1427674_a_at (Mouse Genome 430 2.0 Array)   1459972_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000646
Ensembl peptide - ENSMUSP00000091532
Ensembl peptide - ENSMUSP00000115660
Ensembl peptide - ENSMUSP00000132041
NCBI entrez gene - 20370     See in Manteia.
MGI - MGI:104745
RefSeq - XM_006532640
RefSeq - NM_001291225
RefSeq - NM_021286
RefSeq - XM_006532636
RefSeq - XM_006532637
RefSeq - XM_006532639
RefSeq Peptide - NP_001278154
RefSeq Peptide - NP_067261
swissprot - F6XNR8
swissprot - Q7TSK2
swissprot - F6SXT0
Ensembl - ENSMUSG00000000632
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sez6aENSDARG00000100876Danio rerio
 sez6bENSDARG00000079414Danio rerio
 SEZ6ENSGALG00000026431Gallus gallus
 SEZ6ENSG00000063015Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sez6l / Q6P1D5 / seizure related 6 homolog like / Q9BYH1*ENSMUSG0000005815343
Q4V9Z5 / Sez6l2 / Seizure 6-like protein 2 / Q6UXD5* / seizure related 6 homolog like 2*ENSMUSG0000003068342
Csmd2 / CUB and Sushi multiple domains 2 / Q7Z408*ENSMUSG0000002880422
Csmd3 / Q80T79 / CUB and sushi domain-containing protein 3 / Q7Z407* / CUB and Sushi multiple domains 3*ENSMUSG0000002231121
Csmd1 / Q923L3 / CUB and sushi domain-containing protein 1 / CUB and Sushi multiple domains 1*ENSMUSG0000006092421
Svep1 / A2AVA0 / Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 / Q4LDE5* / sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1*ENSMUSG0000002836918
Cr2 / complement C3d receptor 2 / P20023*ENSMUSG0000002661615
Cr1l / Q64735 / Mus musculus complement component (3b/4b) receptor 1-like (Cr1l), transcript variant 2, mRNA. / Q2VPA4* / complement C3b/C4b receptor 1 like*ENSMUSG000000164817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000859  CUB domain
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008344 adult locomotory behavior IGI
 biological_processGO:0021680 cerebellar Purkinje cell layer development IGI
 biological_processGO:0050773 regulation of dendrite development IMP
 biological_processGO:0060074 synapse maturation IGI
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:0090036 regulation of protein kinase C signaling IGI
 biological_processGO:1900006 positive regulation of dendrite development IDA
 biological_processGO:2000171 negative regulation of dendrite development IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0043198 dendritic shaft IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0097440 apical dendrite IDA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Coro1atm1Jpie/Coro1atm1Jpie
Genetic Background: involves: 129 * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Coro1atm1Jpie/Coro1atm1Jpie
Genetic Background: involves: 129 * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

Allelic Composition: Sez6tm1.1Sest/Sez6tm1.1Sest
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Coro1atm1Jpie/Coro1atm1Jpie
Genetic Background: involves: 129 * C57BL/6

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Sez6tm1.1Sest/Sez6tm1.1Sest
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apobtm1Mae/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sez6tm1.1Sest/Sez6tm1.1Sest
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sez6tm1.1Sest/Sez6tm1.1Sest
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
Show

Allelic Composition: Sez6tm1.1Sest/Sez6tm1.1Sest
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

Allelic Composition: Sez6tm1.1Sest/Sez6tm1.1Sest
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sez6tm1.1Sest/Sez6tm1.1Sest
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003894 abnormal Purkinje cell innervation "malformation or absence of the supply of nerve fibers that connect to the Purkinje cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sez6tm1.1Sest/Sez6tm1.1Sest
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Sez6tm1.1Sest/Sez6tm1.1Sest
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011268 biphasic excitatory postsynaptic current amplitude "the appearance of two peaks instead of one peak in the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

 MP:0011272 short excitatory postsynaptic current rise time "an decrease in the time required for a signal to change from resting to the peak amplitude value in the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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