ENSMUSG00000016481


Mus musculus

Features
Gene ID: ENSMUSG00000016481
  
Biological name :Cr1l
  
Synonyms : Cr1l / Mus musculus complement component (3b/4b) receptor 1-like (Cr1l), transcript variant 2, mRNA. / Q64735
  
Possible biological names infered from orthology : complement C3b/C4b receptor 1 like / Q2VPA4
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 195097382
Gene end: 195131586
  
Corresponding Affymetrix probe sets: 10361282 (MoGene1.0st)   1422563_at (Mouse Genome 430 2.0 Array)   1430131_at (Mouse Genome 430 2.0 Array)   1438920_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074902
Ensembl peptide - ENSMUSP00000142309
Ensembl peptide - ENSMUSP00000142104
Ensembl peptide - ENSMUSP00000142069
Ensembl peptide - ENSMUSP00000141996
Ensembl peptide - ENSMUSP00000141250
NCBI entrez gene - 12946     See in Manteia.
MGI - MGI:88513
RefSeq - XM_017314176
RefSeq - NM_001355060
RefSeq - NM_013499
RefSeq - XM_006497226
RefSeq - XM_011238928
RefSeq Peptide - NP_001341989
RefSeq Peptide - NP_038527
swissprot - A0A0A6YXN9
swissprot - A0A0A6YXH8
swissprot - A0A0A6YVT1
swissprot - Q64735
swissprot - A0A0A6YXR6
swissprot - A0A0A6YY75
Ensembl - ENSMUSG00000016481
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000045935Gallus gallus
 CR1LENSG00000197721Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cr2 / complement C3d receptor 2 / P20023*ENSMUSG0000002661633
Csmd3 / Q80T79 / CUB and sushi domain-containing protein 3 / Q7Z407* / CUB and Sushi multiple domains 3*ENSMUSG0000002231127
Csmd1 / Q923L3 / CUB and sushi domain-containing protein 1 / CUB and Sushi multiple domains 1*ENSMUSG0000006092426
Csmd2 / CUB and Sushi multiple domains 2 / Q7Z408*ENSMUSG0000002880425
Svep1 / A2AVA0 / Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 / Q4LDE5* / sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1*ENSMUSG0000002836920
Q4V9Z5 / Sez6l2 / Seizure 6-like protein 2 / Q6UXD5* / seizure related 6 homolog like 2*ENSMUSG0000003068317
Sez6l / Q6P1D5 / seizure related 6 homolog like / Q9BYH1*ENSMUSG0000005815315
Sez6 / Q7TSK2 / Seizure protein 6 / Q53EL9* / seizure related 6 homolog*ENSMUSG0000000063215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045916 negative regulation of complement activation IMP
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0002471 abnormal complement cascade "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0004041 increased susceptibility to kidney reperfusion injury "an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttrtm3(TTR*)Kymm/Ttrtm3(TTR*)Kymm
Genetic Background: B6.Cg-Ttrtm3(TTR*)Kymm

Allelic Composition: Cr1ltm1.1Song/Cr1ltm1.1Song,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ttrtm3(TTR*)Kymm/Ttrtm3(TTR*)Kymm
Genetic Background: B6.Cg-Ttrtm3(TTR*)Kymm

Allelic Composition: Cr1ltm1.1Song/Cr1ltm1.1Song,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL

Allelic Composition: Cr1ltm1.1Song/Cr1ltm1.1Song,Vsig4tm1Gne/Vsig4tm1Gne,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * DBA/2 * SJL

 MP:0005028 abnormal trophectoderm "malformed outermost layer of cells in the blastodermic vesicle, which will contact the endometrium and take part in establishing the embryo s means of nutrition" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0005032 abnormal ectoplacental cone 
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Npr2cn/Npr2slw
Genetic Background: involves: AKR/J * C57BL/6 * DDY

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Cd55tm1Song/Cd55tm1Song,Cr1ltm1Hmo/Cr1ltm1Hmo,Vsig4tm1Gne/Vsig4tm1Gne
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttrtm3(TTR*)Kymm/Ttrtm3(TTR*)Kymm
Genetic Background: B6.Cg-Ttrtm3(TTR*)Kymm

Allelic Composition: Cr1ltm1.1Song/Cr1ltm1.1Song,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttrtm3(TTR*)Kymm/Ttrtm3(TTR*)Kymm
Genetic Background: B6.Cg-Ttrtm3(TTR*)Kymm

Allelic Composition: Cr1ltm1.1Song/Cr1ltm1.1Song,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttrtm3(TTR*)Kymm/Ttrtm3(TTR*)Kymm
Genetic Background: B6.Cg-Ttrtm3(TTR*)Kymm

Allelic Composition: Cr1ltm1.1Song/Cr1ltm1.1Song,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr