ENSMUSG00000026616


Mus musculus

Features
Gene ID: ENSMUSG00000026616
  
Biological name :Cr2
  
Synonyms : complement C3d receptor 2 / Cr2
  
Possible biological names infered from orthology : P20023
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 195136811
Gene end: 195176716
  
Corresponding Affymetrix probe sets: 10361292 (MoGene1.0st)   1425289_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080938
Ensembl peptide - ENSMUSP00000147804
Ensembl peptide - ENSMUSP00000142147
Ensembl peptide - ENSMUSP00000141706
Ensembl peptide - ENSMUSP00000141538
Ensembl peptide - ENSMUSP00000141276
Ensembl peptide - ENSMUSP00000044261
NCBI entrez gene - 12902     See in Manteia.
MGI - MGI:88489
RefSeq - XM_017314050
RefSeq - XM_006497225
RefSeq - XM_006497221
RefSeq - XM_006497222
RefSeq - NM_007758
RefSeq - XM_006497224
RefSeq Peptide - NP_031784
swissprot - Q32M14
swissprot - Q9DC83
swissprot - E9Q3S5
swissprot - A0A0A6YWG3
swissprot - A0A0A6YWU7
swissprot - A0A0A6YXU7
swissprot - A0A1B0GS59
Ensembl - ENSMUSG00000026616
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000045935Gallus gallus
 CR2ENSG00000117322Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Csmd3 / Q80T79 / CUB and sushi domain-containing protein 3 / Q7Z407* / CUB and Sushi multiple domains 3*ENSMUSG0000002231126
Csmd1 / Q923L3 / CUB and sushi domain-containing protein 1 / CUB and Sushi multiple domains 1*ENSMUSG0000006092426
Csmd2 / CUB and Sushi multiple domains 2 / Q7Z408*ENSMUSG0000002880425
Svep1 / A2AVA0 / Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 / Q4LDE5* / sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1*ENSMUSG0000002836925
Sez6 / Q7TSK2 / Seizure protein 6 / Q53EL9* / seizure related 6 homolog*ENSMUSG0000000063215
Q4V9Z5 / Sez6l2 / Seizure 6-like protein 2 / Q6UXD5* / seizure related 6 homolog like 2*ENSMUSG0000003068314
Cr1l / Q64735 / Mus musculus complement component (3b/4b) receptor 1-like (Cr1l), transcript variant 2, mRNA. / Q2VPA4* / complement C3b/C4b receptor 1 like*ENSMUSG0000001648114
Sez6l / Q6P1D5 / seizure related 6 homolog like / Q9BYH1*ENSMUSG0000005815314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0042100 B cell proliferation IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0001848 complement binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acadltm1Uab/Acadl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acadltm1Uab/Acadl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Acadltm1Uab/Acadl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Cr2tm1Crr/Cr2tm1Crr,Ggta1tm1Jbl/Ggta1tm1Jbl
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cr2tm1Tft/Cr2tm1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cr2tm1Tft/Cr2tm1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cr2tm2.1Jhws/Cr2tm2.1Jhws
Genetic Background: B6.129-Cr2tm2.1Jhws

Allelic Composition: Cr2tm1.1Jhws/Cr2tm1.1Jhws
Genetic Background: Not Specified

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Acadltm1Uab/Acadl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pkd1tm1Jzh/Pkd1+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)

Allelic Composition: Cr2tm1Hmo/Cr2tm1Hmo
Genetic Background: B6.129S7-Cr2tm1Hmo

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pkd1tm1Jzh/Pkd1+
Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Epn1tm1Ocr/Epn1tm1Ocr,Epn2tm1Ocr/Epn2+
Genetic Background: B6.129X1-Epn1tm1Ocr Epn2tm1Ocr

Allelic Composition: Cr2tm1Hmo/Cr2tm1Hmo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acadltm1Uab/Acadl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cr2tm2.1Jhws/Cr2tm2.1Jhws
Genetic Background: B6.129-Cr2tm2.1Jhws

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Epn1tm1Ocr/Epn1tm1Ocr,Epn2tm1Ocr/Epn2+
Genetic Background: B6.129X1-Epn1tm1Ocr Epn2tm1Ocr

Allelic Composition: Cr2tm1Hmo/Cr2tm1Hmo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004940 abnormal B-1 B cell morphology "any structural anomaly in the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas" [CL:0000819, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cr2tm1Hmo/Cr2tm1Hmo
Genetic Background: B6.129S7-Cr2tm1Hmo

 MP:0008095 abnormal memory B cell differentiation "atypical production of or inability to produce distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Epn1tm1Ocr/Epn1tm1Ocr,Epn2tm1Ocr/Epn2+
Genetic Background: B6.129X1-Epn1tm1Ocr Epn2tm1Ocr

Allelic Composition: Cr2tm1Hmo/Cr2tm1Hmo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cr2tm1.1Jhws/Cr2tm1.1Jhws
Genetic Background: Not Specified

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Btkxid/Y,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129S4/SvJae * CBA/CaHN

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Btkxid/Y,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129S4/SvJae * CBA/CaHN

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Cr2tm2.1Jhws/Cr2tm2.1Jhws
Genetic Background: B6.129-Cr2tm2.1Jhws

Allelic Composition: Cr2tm1.1Jhws/Cr2tm1.1Jhws
Genetic Background: Not Specified

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Epn1tm1Ocr/Epn1tm1Ocr,Epn2tm1Ocr/Epn2+
Genetic Background: B6.129X1-Epn1tm1Ocr Epn2tm1Ocr

Allelic Composition: Cr2tm1Hmo/Cr2tm1Hmo
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cr2tm1Tft/Cr2tm1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cr2tm1Tft/Cr2tm1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cr2tm1Tft/Cr2tm1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cr2tm1.1Jhws/Cr2tm1.1Jhws
Genetic Background: Not Specified

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cr2tm1Tft/Cr2tm1Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cr2tm2.1Jhws/Cr2tm2.1Jhws
Genetic Background: B6.129-Cr2tm2.1Jhws

Allelic Composition: Cr2tm1.1Jhws/Cr2tm1.1Jhws
Genetic Background: Not Specified

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008897 decreased IgG2c level "less than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cr2tm1.1Jhws/Cr2tm1.1Jhws
Genetic Background: Not Specified

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cr2tm1Crr/Cr2tm1Crr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cr2tm1.1Jhws/Cr2tm1.1Jhws
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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