ENSMUSG00000058153


Mus musculus

Features
Gene ID: ENSMUSG00000058153
  
Biological name :Sez6l
  
Synonyms : Q6P1D5 / seizure related 6 homolog like / Sez6l
  
Possible biological names infered from orthology : Q9BYH1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 112419151
Gene end: 112577185
  
Corresponding Affymetrix probe sets: 10532542 (MoGene1.0st)   1424764_at (Mouse Genome 430 2.0 Array)   1440128_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148791
Ensembl peptide - ENSMUSP00000074847
Ensembl peptide - ENSMUSP00000148806
Ensembl peptide - ENSMUSP00000078454
Ensembl peptide - ENSMUSP00000143395
Ensembl peptide - ENSMUSP00000143160
NCBI entrez gene - 56747     See in Manteia.
MGI - MGI:1935121
RefSeq - XM_006535154
RefSeq - XM_006535158
RefSeq - XM_006535157
RefSeq - XM_006535156
RefSeq - XM_006535155
RefSeq - NM_001253916
RefSeq - NM_001253917
RefSeq - NM_019982
RefSeq Peptide - NP_001240845
RefSeq Peptide - NP_001240846
RefSeq Peptide - NP_064366
swissprot - Q6P1D5
swissprot - A0A1D5RMJ7
swissprot - A0A0G2JFG4
swissprot - A0A0G2JG23
swissprot - A0A0R4J0Y4
swissprot - A0A1D5RMI4
Ensembl - ENSMUSG00000058153
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sez6lENSDARG00000100594Danio rerio
 SEZ6LENSGALG00000032415Gallus gallus
 SEZ6LENSG00000100095Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sez6 / Q7TSK2 / Seizure protein 6 / Q53EL9* / seizure related 6 homolog*ENSMUSG0000000063244
Q4V9Z5 / Sez6l2 / Seizure 6-like protein 2 / Q6UXD5* / seizure related 6 homolog like 2*ENSMUSG0000003068342
Csmd3 / Q80T79 / CUB and sushi domain-containing protein 3 / Q7Z407* / CUB and Sushi multiple domains 3*ENSMUSG0000002231122
Csmd2 / CUB and Sushi multiple domains 2 / Q7Z408*ENSMUSG0000002880422
Csmd1 / Q923L3 / CUB and sushi domain-containing protein 1 / CUB and Sushi multiple domains 1*ENSMUSG0000006092421
Svep1 / A2AVA0 / Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 / Q4LDE5* / sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1*ENSMUSG0000002836919
Cr2 / complement C3d receptor 2 / P20023*ENSMUSG0000002661615
Cr1l / Q64735 / Mus musculus complement component (3b/4b) receptor 1-like (Cr1l), transcript variant 2, mRNA. / Q2VPA4* / complement C3b/C4b receptor 1 like*ENSMUSG000000164817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR000859  CUB domain
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008344 adult locomotory behavior IGI
 biological_processGO:0021680 cerebellar Purkinje cell layer development IGI
 biological_processGO:0060074 synapse maturation IGI
 biological_processGO:0090036 regulation of protein kinase C signaling IGI
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apobtm1Mae/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

 MP:0003894 abnormal Purkinje cell innervation "malformation or absence of the supply of nerve fibers that connect to the Purkinje cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Setxtm1b(EUCOMM)Wtsi/Setxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Setxtm1b(EUCOMM)Wtsi/Ics

 MP:0011268 biphasic excitatory postsynaptic current amplitude "the appearance of two peaks instead of one peak in the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

 MP:0011272 short excitatory postsynaptic current rise time "an decrease in the time required for a signal to change from resting to the peak amplitude value in the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Sez6tm1Hta/Sez6tm1Hta,Sez6ltm1Hta/Sez6ltm1Hta,Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic Background: involves: 129 * C57BL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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