ENSMUSG00000022548


Mus musculus

Features
Gene ID: ENSMUSG00000022548
  
Biological name :Apod
  
Synonyms : Apod / Apolipoprotein D / P51910
  
Possible biological names infered from orthology : P05090
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B2
Gene start: 31296192
Gene end: 31314808
  
Corresponding Affymetrix probe sets: 10439009 (MoGene1.0st)   1416371_at (Mouse Genome 430 2.0 Array)   1444564_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110885
Ensembl peptide - ENSMUSP00000119827
NCBI entrez gene - 11815     See in Manteia.
MGI - MGI:88056
RefSeq - NM_001301354
RefSeq - NM_001301353
RefSeq - NM_007470
RefSeq Peptide - NP_001288282
RefSeq Peptide - NP_001288283
RefSeq Peptide - NP_031496
swissprot - P51910
Ensembl - ENSMUSG00000022548
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apoda.1ENSDARG00000060345Danio rerio
 apoda.2ENSDARG00000060350Danio rerio
 apodbENSDARG00000057437Danio rerio
 APODENSGALG00000006995Gallus gallus
 APODENSG00000189058Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000566  Lipocalin/cytosolic fatty-acid binding domain
 IPR002345  Lipocalin
 IPR002969  Apolipoprotein D
 IPR012674  Calycin
 IPR022271  Lipocalin, ApoD type
 IPR022272  Lipocalin family conserved site
 IPR026222  Apolipoprotein D, vertebrates


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species ISO
 biological_processGO:0006006 glucose metabolic process ISS
 biological_processGO:0006629 lipid metabolic process ISO
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007420 brain development ISS
 biological_processGO:0007568 aging ISS
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway ISS
 biological_processGO:0014012 peripheral nervous system axon regeneration ISS
 biological_processGO:0042246 tissue regeneration ISS
 biological_processGO:0042308 negative regulation of protein import into nucleus ISS
 biological_processGO:0042493 response to drug ISS
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation ISS
 biological_processGO:0048678 response to axon injury ISS
 biological_processGO:0051895 negative regulation of focal adhesion assembly ISO
 biological_processGO:0060588 negative regulation of lipoprotein lipid oxidation IMP
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production ISO
 biological_processGO:1900016 negative regulation of cytokine production involved in inflammatory response ISS
 biological_processGO:2000098 negative regulation of smooth muscle cell-matrix adhesion ISO
 biological_processGO:2000405 negative regulation of T cell migration ISO
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0022626 cytosolic ribosome ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015485 cholesterol binding ISS
 molecular_functionGO:0036094 small molecule binding IEA


Pathways (from Reactome)
Pathway description
Transport of fatty acids


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv
Genetic Background: involves: C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv
Genetic Background: involves: C57BL/6

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Stat3*)Sbkv/Gt(ROSA)26Sortm1(Stat3*)Sbkv
Genetic Background: involves: C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022548 Apod / P51910 / Apolipoprotein D / P05090*  / complex






 

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