ENSMUSG00000023979


Mus musculus

Features
Gene ID: ENSMUSG00000023979
  
Biological name :Guca1b
  
Synonyms : Guanylyl cyclase-activating protein 2 / Guca1b / Q8VBV8
  
Possible biological names infered from orthology : guanylate cyclase activator 1B / Q9UMX6
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: C
Gene start: 47385393
Gene end: 47392967
  
Corresponding Affymetrix probe sets: 10445664 (MoGene1.0st)   1425138_at (Mouse Genome 430 2.0 Array)   1425441_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126799
Ensembl peptide - ENSMUSP00000024774
NCBI entrez gene - 107477     See in Manteia.
MGI - MGI:1194489
RefSeq - NM_146079
RefSeq - XM_006523462
RefSeq Peptide - NP_666191
swissprot - E9PWU1
swissprot - Q8VBV8
Ensembl - ENSMUSG00000023979
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 guca1bENSDARG00000013393Danio rerio
 GUCA1BENSGALG00000001418Gallus gallus
 GUCA1BENSG00000112599Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Guca1a / P43081 / Guanylyl cyclase-activating protein 1 / P43080* / guanylate cyclase activator 1A*ENSMUSG0000002398242
Ncald / Q91X97 / Neurocalcin-delta / P61601*ENSMUSG0000005135941
Hpcal1 / P62748 / Hippocalcin-like protein 1 / P37235* / hippocalcin like 1*ENSMUSG0000007137941
Hpca / P84075 / Neuron-specific calcium-binding protein hippocalcin / P84074* / hippocalcin*ENSMUSG0000002878540
Vsnl1 / P62761 / visinin-like 1 / P62760*ENSMUSG0000005445939
Hpcal4 / Q8BGZ1 / hippocalcin-like 4 / Q9UM19*ENSMUSG0000004609338
Ncs1 / Q8BNY6 / Neuronal calcium sensor 1 / P62166*ENSMUSG0000006266136
Rcvrn / P34057 / recoverin / P35243*ENSMUSG0000002090732
Kcnip1 / Q9JJ57 / Kv channel-interacting protein 1 / Q9NZI2* / potassium voltage-gated channel interacting protein 1*ENSMUSG0000005351931
Kcnip3 / Q9QXT8 / Kv channel interacting protein 3, calsenilin / Q9Y2W7* / potassium voltage-gated channel interacting protein 3*ENSMUSG0000007905630
Kcnip2 / Q9JJ69 / Kv channel-interacting protein 2 / Q9NS61* / potassium voltage-gated channel interacting protein 2*ENSMUSG0000002522129
Kcnip4 / Q6PHZ8 / Kv channel interacting protein 4 / Q6PIL6* / potassium voltage-gated channel interacting protein 4*ENSMUSG0000002908828


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR015756  Guanylate cyclase activating protein 2
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0007602 phototransduction IMP
 biological_processGO:0031282 regulation of guanylate cyclase activity IGI
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IEA
 biological_processGO:0050896 response to stimulus IEA
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008048 calcium sensitive guanylate cyclase activator activity IDA
 molecular_functionGO:0030249 guanylate cyclase regulator activity IGI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Guca1btm1Amd/Guca1btm1Amd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cngb1tm1.1Glf/Cngb1tm1.1Glf,Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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