ENSMUSG00000053519


Mus musculus

Features
Gene ID: ENSMUSG00000053519
  
Biological name :Kcnip1
  
Synonyms : Kcnip1 / Kv channel-interacting protein 1 / Q9JJ57
  
Possible biological names infered from orthology : potassium voltage-gated channel interacting protein 1 / Q9NZI2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A4
Gene start: 33629339
Gene end: 33993152
  
Corresponding Affymetrix probe sets: 10385096 (MoGene1.0st)   1416785_at (Mouse Genome 430 2.0 Array)   1433156_at (Mouse Genome 430 2.0 Array)   1448459_at (Mouse Genome 430 2.0 Array)   1454504_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069063
Ensembl peptide - ENSMUSP00000098919
Ensembl peptide - ENSMUSP00000104964
NCBI entrez gene - 70357     See in Manteia.
MGI - MGI:1917607
RefSeq - XM_017314755
RefSeq - NM_001190885
RefSeq - NM_001190886
RefSeq - NM_001290690
RefSeq - NM_027398
RefSeq - XM_006514803
RefSeq - XM_017314751
RefSeq - XM_017314752
RefSeq - XM_017314753
RefSeq - XM_017314754
RefSeq Peptide - NP_001177814
RefSeq Peptide - NP_001177815
RefSeq Peptide - NP_001277619
RefSeq Peptide - NP_081674
swissprot - Q3YAB6
swissprot - Q9JJ57
Ensembl - ENSMUSG00000053519
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnip1bENSDARG00000034808Danio rerio
 KCNIP1ENSGALG00000002132Gallus gallus
 KCNIP1ENSG00000182132Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnip4 / Q6PHZ8 / Kv channel interacting protein 4 / Q6PIL6* / potassium voltage-gated channel interacting protein 4*ENSMUSG0000002908867
Kcnip2 / Q9JJ69 / Kv channel-interacting protein 2 / Q9NS61* / potassium voltage-gated channel interacting protein 2*ENSMUSG0000002522163
Kcnip3 / Q9QXT8 / Kv channel interacting protein 3, calsenilin / Q9Y2W7* / potassium voltage-gated channel interacting protein 3*ENSMUSG0000007905661
Ncs1 / Q8BNY6 / Neuronal calcium sensor 1 / P62166*ENSMUSG0000006266137
Vsnl1 / P62761 / visinin-like 1 / P62760*ENSMUSG0000005445936
Hpca / P84075 / Neuron-specific calcium-binding protein hippocalcin / P84074* / hippocalcin*ENSMUSG0000002878534
Hpcal4 / Q8BGZ1 / hippocalcin-like 4 / Q9UM19*ENSMUSG0000004609334
Hpcal1 / P62748 / Hippocalcin-like protein 1 / P37235* / hippocalcin like 1*ENSMUSG0000007137934
Ncald / Q91X97 / Neurocalcin-delta / P61601*ENSMUSG0000005135933
Guca1b / Q8VBV8 / Guanylyl cyclase-activating protein 2 / Q9UMX6* / guanylate cyclase activator 1B*ENSMUSG0000002397928
Rcvrn / P34057 / recoverin / P35243*ENSMUSG0000002090728
Guca1a / P43081 / Guanylyl cyclase-activating protein 1 / P43080* / guanylate cyclase activator 1A*ENSMUSG0000002398224


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:1901379 regulation of potassium ion transmembrane transport ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane ISO
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0015459 potassium channel regulator activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Phase 1 - inactivation of fast Na+ channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Mapttm2Arbr/?,Runx1tm3Spe/Runx1tm1(cre/Esr1*)Ims
Genetic Background: involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm2Arbr/?,Runx1tm3Spe/Runx1tm1(cre/Esr1*)Ims
Genetic Background: involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053519 Kcnip1 / Q9JJ57 / Kv channel-interacting protein 1 / Q9NZI2* / potassium voltage-gated channel interacting protein 1*  / complex
 ENSMUSG00000025221 Kcnip2 / Q9JJ69 / Kv channel-interacting protein 2 / Q9NS61* / potassium voltage-gated channel interacting protein 2*  / complex
 ENSMUSG00000079056 Kcnip3 / Q9QXT8 / Kv channel interacting protein 3, calsenilin / Q9Y2W7* / potassium voltage-gated channel interacting protein 3*  / complex
 ENSMUSG00000009731 Kcnd1 / Q03719 / Potassium voltage-gated channel subfamily D member 1 / Q9NSA2*  / complex
 ENSMUSG00000040896 Kcnd3 / Q9Z0V1 / potassium voltage-gated channel, Shal-related family, member 3 / Q9UK17* / potassium voltage-gated channel subfamily D member 3*  / complex
 ENSMUSG00000060882 Kcnd2 / Q9Z0V2 / Potassium voltage-gated channel subfamily D member 2 / Q9NZV8*  / complex
 ENSMUSG00000029088 Kcnip4 / Q6PHZ8 / Kv channel interacting protein 4 / Q6PIL6* / potassium voltage-gated channel interacting protein 4*  / complex






 

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