ENSMUSG00000062661


Mus musculus

Features
Gene ID: ENSMUSG00000062661
  
Biological name :Ncs1
  
Synonyms : Ncs1 / Neuronal calcium sensor 1 / Q8BNY6
  
Possible biological names infered from orthology : P62166
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 31245823
Gene end: 31295989
  
Corresponding Affymetrix probe sets: 10471129 (MoGene1.0st)   1434887_at (Mouse Genome 430 2.0 Array)   1450146_at (Mouse Genome 430 2.0 Array)   1460293_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142269
Ensembl peptide - ENSMUSP00000000199
NCBI entrez gene - 14299     See in Manteia.
MGI - MGI:109166
RefSeq - NM_019681
RefSeq Peptide - NP_062655
swissprot - A0A0A6YY43
swissprot - Q8BNY6
Ensembl - ENSMUSG00000062661
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncs1aENSDARG00000055229Danio rerio
 ncs1bENSDARG00000054186Danio rerio
 NCS1ENSGALG00000012710Gallus gallus
 NCS1ENSG00000107130Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hpcal1 / P62748 / Hippocalcin-like protein 1 / P37235* / hippocalcin like 1*ENSMUSG0000007137959
Ncald / Q91X97 / Neurocalcin-delta / P61601*ENSMUSG0000005135959
Hpca / P84075 / Neuron-specific calcium-binding protein hippocalcin / P84074* / hippocalcin*ENSMUSG0000002878558
Vsnl1 / P62761 / visinin-like 1 / P62760*ENSMUSG0000005445957
Hpcal4 / Q8BGZ1 / hippocalcin-like 4 / Q9UM19*ENSMUSG0000004609356
Kcnip1 / Q9JJ57 / Kv channel-interacting protein 1 / Q9NZI2* / potassium voltage-gated channel interacting protein 1*ENSMUSG0000005351945
Rcvrn / P34057 / recoverin / P35243*ENSMUSG0000002090745
Kcnip4 / Q6PHZ8 / Kv channel interacting protein 4 / Q6PIL6* / potassium voltage-gated channel interacting protein 4*ENSMUSG0000002908844
Kcnip2 / Q9JJ69 / Kv channel-interacting protein 2 / Q9NS61* / potassium voltage-gated channel interacting protein 2*ENSMUSG0000002522144
Kcnip3 / Q9QXT8 / Kv channel interacting protein 3, calsenilin / Q9Y2W7* / potassium voltage-gated channel interacting protein 3*ENSMUSG0000007905644
Guca1b / Q8VBV8 / Guanylyl cyclase-activating protein 2 / Q9UMX6* / guanylate cyclase activator 1B*ENSMUSG0000002397938
Guca1a / P43081 / Guanylyl cyclase-activating protein 1 / P43080* / guanylate cyclase activator 1A*ENSMUSG0000002398235


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0045921 positive regulation of exocytosis IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0050806 positive regulation of synaptic transmission TAS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0031045 dense core granule IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nab2tm1b(EUCOMM)Hmgu/Nab2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nab2tm1b(EUCOMM)Hmgu/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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