ENSMUSG00000028785


Mus musculus

Features
Gene ID: ENSMUSG00000028785
  
Biological name :Hpca
  
Synonyms : Hpca / Neuron-specific calcium-binding protein hippocalcin / P84075
  
Possible biological names infered from orthology : hippocalcin / P84074
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 129111570
Gene end: 129122036
  
Corresponding Affymetrix probe sets: 10516544 (MoGene1.0st)   1425833_a_at (Mouse Genome 430 2.0 Array)   1450930_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115619
Ensembl peptide - ENSMUSP00000119178
Ensembl peptide - ENSMUSP00000129548
Ensembl peptide - ENSMUSP00000120655
Ensembl peptide - ENSMUSP00000030572
Ensembl peptide - ENSMUSP00000093486
Ensembl peptide - ENSMUSP00000112143
Ensembl peptide - ENSMUSP00000112145
Ensembl peptide - ENSMUSP00000115031
NCBI entrez gene - 15444     See in Manteia.
MGI - MGI:1336200
RefSeq - XM_006502776
RefSeq - XM_006502777
RefSeq - NM_001130419
RefSeq - XM_006502775
RefSeq - NM_001286081
RefSeq - NM_001286083
RefSeq - NM_010471
RefSeq - XM_011240446
RefSeq Peptide - NP_001273010
RefSeq Peptide - NP_001123891
RefSeq Peptide - NP_001273012
RefSeq Peptide - NP_034601
swissprot - P84075
swissprot - E9PV73
swissprot - A2A7R5
swissprot - A2A7R6
Ensembl - ENSMUSG00000028785
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HPCAENSGALG00000003573Gallus gallus
 HPCAENSG00000121905Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hpcal1 / P62748 / Hippocalcin-like protein 1 / P37235* / hippocalcin like 1*ENSMUSG0000007137994
Ncald / Q91X97 / Neurocalcin-delta / P61601*ENSMUSG0000005135988
Hpcal4 / Q8BGZ1 / hippocalcin-like 4 / Q9UM19*ENSMUSG0000004609367
Vsnl1 / P62761 / visinin-like 1 / P62760*ENSMUSG0000005445967
Ncs1 / Q8BNY6 / Neuronal calcium sensor 1 / P62166*ENSMUSG0000006266158
Rcvrn / P34057 / recoverin / P35243*ENSMUSG0000002090751
Guca1b / Q8VBV8 / Guanylyl cyclase-activating protein 2 / Q9UMX6* / guanylate cyclase activator 1B*ENSMUSG0000002397942
Kcnip2 / Q9JJ69 / Kv channel-interacting protein 2 / Q9NS61* / potassium voltage-gated channel interacting protein 2*ENSMUSG0000002522141
Kcnip1 / Q9JJ57 / Kv channel-interacting protein 1 / Q9NZI2* / potassium voltage-gated channel interacting protein 1*ENSMUSG0000005351940
Kcnip4 / Q6PHZ8 / Kv channel interacting protein 4 / Q6PIL6* / potassium voltage-gated channel interacting protein 4*ENSMUSG0000002908838
Kcnip3 / Q9QXT8 / Kv channel interacting protein 3, calsenilin / Q9Y2W7* / potassium voltage-gated channel interacting protein 3*ENSMUSG0000007905637
Guca1a / P43081 / Guanylyl cyclase-activating protein 1 / P43080* / guanylate cyclase activator 1A*ENSMUSG0000002398235


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007420 brain development IEA
 biological_processGO:0010518 positive regulation of phospholipase activity IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0031283 negative regulation of guanylate cyclase activity IEA
 biological_processGO:0031584 activation of phospholipase D activity IEA
 biological_processGO:0045762 positive regulation of adenylate cyclase activity IEA
 biological_processGO:0048839 inner ear development IDA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0071257 cellular response to electrical stimulus IEA
 biological_processGO:0071277 cellular response to calcium ion ISO
 biological_processGO:0090314 positive regulation of protein targeting to membrane IEA
 biological_processGO:1901385 regulation of voltage-gated calcium channel activity ISS
 biological_processGO:1901986 response to ketamine IEA
 biological_processGO:1902065 response to L-glutamate IEA
 biological_processGO:1904009 cellular response to monosodium glutamate IEA
 biological_processGO:1904010 response to Aroclor 1254 IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane ISS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0032590 dendrite membrane IEA
 cellular_componentGO:0032809 neuronal cell body membrane IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0044327 dendritic spine head IEA
 molecular_functionGO:0003779 actin binding ISS
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042802 identical protein binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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