ENSMUSG00000023982


Mus musculus

Features
Gene ID: ENSMUSG00000023982
  
Biological name :Guca1a
  
Synonyms : Guanylyl cyclase-activating protein 1 / Guca1a / P43081
  
Possible biological names infered from orthology : guanylate cyclase activator 1A / P43080
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 47394560
Gene end: 47400584
  
Corresponding Affymetrix probe sets: 10451551 (MoGene1.0st)   1421061_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060027
NCBI entrez gene - 14913     See in Manteia.
MGI - MGI:102770
RefSeq - NM_008189
RefSeq - XM_011246296
RefSeq Peptide - NP_032215
swissprot - P43081
Ensembl - ENSMUSG00000023982
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 guca1eENSDARG00000101567Danio rerio
 si:ch211-103a14.5ENSDARG00000100747Danio rerio
 GUCA1AENSGALG00000001431Gallus gallus
 GUCA1AENSG00000048545Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Guca1b / Q8VBV8 / Guanylyl cyclase-activating protein 2 / Q9UMX6* / guanylate cyclase activator 1B*ENSMUSG0000002397942
Hpcal1 / P62748 / Hippocalcin-like protein 1 / P37235* / hippocalcin like 1*ENSMUSG0000007137935
Ncald / Q91X97 / Neurocalcin-delta / P61601*ENSMUSG0000005135934
Hpca / P84075 / Neuron-specific calcium-binding protein hippocalcin / P84074* / hippocalcin*ENSMUSG0000002878533
Vsnl1 / P62761 / visinin-like 1 / P62760*ENSMUSG0000005445933
Ncs1 / Q8BNY6 / Neuronal calcium sensor 1 / P62166*ENSMUSG0000006266133
Hpcal4 / Q8BGZ1 / hippocalcin-like 4 / Q9UM19*ENSMUSG0000004609333
Rcvrn / P34057 / recoverin / P35243*ENSMUSG0000002090732
Kcnip1 / Q9JJ57 / Kv channel-interacting protein 1 / Q9NZI2* / potassium voltage-gated channel interacting protein 1*ENSMUSG0000005351927
Kcnip2 / Q9JJ69 / Kv channel-interacting protein 2 / Q9NS61* / potassium voltage-gated channel interacting protein 2*ENSMUSG0000002522126
Kcnip3 / Q9QXT8 / Kv channel interacting protein 3, calsenilin / Q9Y2W7* / potassium voltage-gated channel interacting protein 3*ENSMUSG0000007905625
Kcnip4 / Q6PHZ8 / Kv channel interacting protein 4 / Q6PIL6* / potassium voltage-gated channel interacting protein 4*ENSMUSG0000002908824


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR033022  Guanylyl cyclase-activating protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0007602 phototransduction IMP
 biological_processGO:0030828 obsolete positive regulation of cGMP biosynthetic process IEA
 biological_processGO:0031282 regulation of guanylate cyclase activity IGI
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0071277 cellular response to calcium ion ISS
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0008048 calcium sensitive guanylate cyclase activator activity IDA
 molecular_functionGO:0030249 guanylate cyclase regulator activity IGI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cngb1tm1.1Glf/Cngb1tm1.1Glf,Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

Allelic Composition: Guca1atm1.1Hunt/Guca1a+
Genetic Background: involves: 129/Sv

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

Allelic Composition: Guca1atm1Itl/Guca1atm1Itl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1a+
Genetic Background: involves: 129/Sv

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Slc2a4tm1Mch/Slc2a4tm1Mch
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

Allelic Composition: Guca1atm1.1Hunt/Guca1a+
Genetic Background: involves: 129/Sv

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1a+
Genetic Background: involves: 129/Sv

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1a+
Genetic Background: involves: 129/Sv

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1a+
Genetic Background: involves: 129/Sv

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1a+
Genetic Background: involves: 129/Sv

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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