ENSMUSG00000024842


Mus musculus

Features
Gene ID: ENSMUSG00000024842
  
Biological name :Cabp4
  
Synonyms : Cabp4 / Calcium-binding protein 4 / Q8VHC5
  
Possible biological names infered from orthology : P57796
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 4135425
Gene end: 4139609
  
Corresponding Affymetrix probe sets: 10464612 (MoGene1.0st)   1425878_at (Mouse Genome 430 2.0 Array)   1456936_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025761
NCBI entrez gene - 73660     See in Manteia.
MGI - MGI:1920910
RefSeq - NM_144532
RefSeq - XM_017318298
RefSeq Peptide - NP_653115
swissprot - Q8VHC5
Ensembl - ENSMUSG00000024842
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cabp4ENSDARG00000008866Danio rerio
 si:cabz01076231.1ENSDARG00000105631Danio rerio
 CABP4ENSG00000175544Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cabp2 / calcium binding protein 2 / Q9NPB3*ENSMUSG0000002485741
Cabp1 / Q9JLK7 / Calcium-binding protein 1 / Q9NZU7*ENSMUSG0000002954438
Cabp5 / Q9JLK3 / Calcium-binding protein 5 / Q9NP86*ENSMUSG0000000564935
Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*ENSMUSG0000000117525
Calm3 / P0DP27 / P0DP28 / P0DP26 / Calmodulin-1 / CALM1* / P0DP23*ENSMUSG0000001937024
Calm2 / P0DP27 / P0DP28 / P0DP26 / Calmodulin-1 / CALM3* / P0DP25* / calmodulin 3*ENSMUSG0000003643824
Calml3 / Q9D6P8 / Calmodulin-like protein 3 / P27482* / calmodulin like 3*ENSMUSG0000006313023
Tnnc2 / P20801 / Troponin C, skeletal muscle / P02585* / troponin C2, fast skeletal type*ENSMUSG0000001730021
Tnnc1 / P19123 / Troponin C, slow skeletal and cardiac muscles / P63316* / troponin C1, slow skeletal and cardiac type*ENSMUSG0000009189820
Calm4 / Q9JM83 / Calmodulin-4 / Q9NZT1* / CALML5* / calmodulin like 5*ENSMUSG0000003376520
Calm5 / calmodulin 5 / CALML5* / Q9NZT1* / calmodulin like 5*ENSMUSG0000009926915
Calml4 / Q91WQ9 / Calmodulin-like protein 4 / Q96GE6* / calmodulin like 4*ENSMUSG0000003224614


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR033014  Calcium-binding protein 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007601 visual perception ISO
 biological_processGO:0007602 phototransduction IMP
 biological_processGO:0008594 photoreceptor cell morphogenesis IMP
 biological_processGO:0046549 retinal cone cell development IMP
 biological_processGO:0060040 retinal bipolar neuron differentiation IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005246 calcium channel regulator activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0008519 thin retinal outer plexiform layer "reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: involves: C3H * C57BL/6

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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