ENSMUSG00000019370


Mus musculus

Features
Gene ID: ENSMUSG00000019370
  
Biological name :Calm3
  
Synonyms : Calm3 / Calmodulin-1 / P0DP26 / P0DP27 / P0DP28
  
Possible biological names infered from orthology : CALM1 / P0DP23
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A2
Gene start: 16915379
Gene end: 16924114
  
Corresponding Affymetrix probe sets: 10560304 (MoGene1.0st)   1426710_at (Mouse Genome 430 2.0 Array)   1450864_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019514
Ensembl peptide - ENSMUSP00000133559
Ensembl peptide - ENSMUSP00000134395
NCBI entrez gene - 12315     See in Manteia.
MGI - MGI:103249
RefSeq - NM_007590
RefSeq Peptide - NP_031616
swissprot - G3UX57
swissprot - G3UZ90
swissprot - P0DP26
swissprot - P0DP27
swissprot - P0DP28
Ensembl - ENSMUSG00000019370
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 calm1bENSDARG00000034187Danio rerio
 CALM2ENSGALG00000010023Gallus gallus
 CALM1ENSG00000198668Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Calm2 / P0DP27 / P0DP28 / P0DP26 / Calmodulin-1 / CALM3* / P0DP25* / calmodulin 3*ENSMUSG00000036438100
Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*ENSMUSG0000000117599
Calml3 / Q9D6P8 / Calmodulin-like protein 3 / P27482* / calmodulin like 3*ENSMUSG0000006313087
Tnnc2 / P20801 / Troponin C, skeletal muscle / P02585* / troponin C2, fast skeletal type*ENSMUSG0000001730052
Tnnc1 / P19123 / Troponin C, slow skeletal and cardiac muscles / P63316* / troponin C1, slow skeletal and cardiac type*ENSMUSG0000009189852
Calm4 / Q9JM83 / Calmodulin-4 / Q9NZT1* / CALML5* / calmodulin like 5*ENSMUSG0000003376545
Calml4 / Q91WQ9 / Calmodulin-like protein 4 / Q96GE6* / calmodulin like 4*ENSMUSG0000003224644
Cabp2 / calcium binding protein 2 / Q9NPB3*ENSMUSG0000002485744
Cabp5 / Q9JLK3 / Calcium-binding protein 5 / Q9NP86*ENSMUSG0000000564944
Cabp4 / Q8VHC5 / Calcium-binding protein 4 / P57796*ENSMUSG0000002484243
Cabp1 / Q9JLK7 / Calcium-binding protein 1 / Q9NZU7*ENSMUSG0000002954442
Calm5 / calmodulin 5 / CALML5* / Q9NZT1* / calmodulin like 5*ENSMUSG0000009926934


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IDA
 biological_processGO:0043388 positive regulation of DNA binding IDA
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity ISS
 biological_processGO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity ISS
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IGI
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0019855 calcium channel inhibitor activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
CaMK IV-mediated phosphorylation of CREB
Calmodulin induced events
Cam-PDE 1 activation
Platelet degranulation
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
PKA activation
Synthesis of IP3 and IP4 in the cytosol
Calcineurin activates NFAT
eNOS activation
Inactivation, recovery and regulation of the phototransduction cascade
Stimuli-sensing channels
FCERI mediated Ca+2 mobilization
Ca2+ pathway
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
CREB phosphorylation through the activation of CaMKK
CREB phosphorylation through the activation of CaMKII
Activation of CaMK IV
Ras activation upon Ca2+ influx through NMDA receptor
Smooth Muscle Contraction
Activation of Ca-permeable Kainate Receptor
VEGFR2 mediated vascular permeability
Phase 0 - rapid depolarisation
Ion homeostasis
CLEC7A (Dectin-1) induces NFAT activation
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RAF/MAP kinase cascade
Glycogen breakdown (glycogenolysis)
Protein methylation
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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