ENSMUSG00000027858


Mus musculus

Features
Gene ID: ENSMUSG00000027858
  
Biological name :Tspan2
  
Synonyms : Q922J6 / tetraspanin 2 / Tspan2
  
Possible biological names infered from orthology : O60636
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 102734529
Gene end: 102801513
  
Corresponding Affymetrix probe sets: 10494821 (MoGene1.0st)   1424567_at (Mouse Genome 430 2.0 Array)   1424568_at (Mouse Genome 430 2.0 Array)   1432417_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142543
Ensembl peptide - ENSMUSP00000142964
Ensembl peptide - ENSMUSP00000029451
Ensembl peptide - ENSMUSP00000113803
NCBI entrez gene - 70747     See in Manteia.
MGI - MGI:1917997
RefSeq - NM_001243132
RefSeq - NM_027533
RefSeq Peptide - NP_001230061
RefSeq Peptide - NP_081809
swissprot - Q9D1X8
swissprot - A0A0G2JDX4
swissprot - Q922J6
swissprot - A0A0G2JEZ7
Ensembl - ENSMUSG00000027858
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tspan2aENSDARG00000003754Danio rerio
 tspan2bENSDARG00000059202Danio rerio
 TSPAN2ENSGALG00000002554Gallus gallus
 O60636ENSG00000134198Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd9 / P40240 / CD9 antigen / P21926* / CD9 molecule*ENSMUSG0000003034249
Cd81 / P35762 / CD81 antigen / P60033* / CD81 molecule*ENSMUSG0000003770643
Q9DCK3 / Tspan4 / tetraspanin 4 / O14817*ENSMUSG0000002551130
Q8R3G9 / Tspan8 / Tetraspanin-8 / P19075*ENSMUSG0000003412729
Q8BJU2 / Tspan9 / Mus musculus tetraspanin 9 (Tspan9), transcript variant 2, mRNA. / O75954* / tetraspanin 9*ENSMUSG0000003035228
Q99J59 / Tspan1 / Tetraspanin-1 / O60635*ENSMUSG0000002869927
Cd53 / Q61451 / Leukocyte surface antigen CD53 / P19397* / CD53 molecule*ENSMUSG0000004074727
Cd82 / P40237 / CD82 antigen / P27701* / CD82 molecule*ENSMUSG0000002721527
Q80WR1 / Tspan18 / Tetraspanin-18 / Q96SJ8*ENSMUSG0000002721725
Cd37 / Q61470 / Leukocyte antigen CD37 / P11049* / CD37 molecule*ENSMUSG0000003079823


Protein motifs (from Interpro)
Interpro ID Name
 IPR000301  Tetraspanin
 IPR008952  Tetraspanin, EC2 domain superfamily
 IPR018499  Tetraspanin/Peripherin
 IPR018503  Tetraspanin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IGI
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0014002 astrocyte development IMP
 biological_processGO:0014005 microglia development IMP
 biological_processGO:0042552 myelination IGI
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0061564 axon development IGI
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043209 myelin sheath IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan

 MP:0010047 axonal spheroids "focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421]
Show

Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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