ENSMUSG00000028463


Mus musculus

Features
Gene ID: ENSMUSG00000028463
  
Biological name :Car9
  
Synonyms : Car9 / Carbonic anhydrase 9 / Q8VHB5
  
Possible biological names infered from orthology : CA9 / Q16790
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A5
Gene start: 43506966
Gene end: 43513729
  
Corresponding Affymetrix probe sets: 10504337 (MoGene1.0st)   1427013_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030183
Ensembl peptide - ENSMUSP00000114493
NCBI entrez gene - 230099     See in Manteia.
MGI - MGI:2447188
RefSeq - XM_006537831
RefSeq - NM_139305
RefSeq Peptide - NP_647466
swissprot - Q3UUZ9
swissprot - Q8VHB5
swissprot - F6XXU0
Ensembl - ENSMUSG00000028463
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ca9ENSDARG00000102300Danio rerio
 CA9ENSGALG00000021340Gallus gallus
 CA9ENSG00000107159Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Car14 / Q9WVT6 / Mus musculus carbonic anhydrase 14 (Car14), transcript variant 2, mRNA. / CA14* / Q9ULX7* / carbonic anhydrase 14*ENSMUSG0000003852630
Car12 / carbonic anhydrase 12 / CA12* / O43570*ENSMUSG0000003237327
Car15 / Q99N23 / Carbonic anhydrase 15 ENSMUSG0000009023622
Car7 / Q9ERQ8 / Carbonic anhydrase 7 / CA7* / P43166*ENSMUSG0000003188322
Car6 / P18761 / Carbonic anhydrase 6 / CA6* / P23280*ENSMUSG0000002897222
Car4 / Q64444 / Carbonic anhydrase 4 / CA4* / P22748*ENSMUSG0000000080521
Car2 / P00920 / Mus musculus carbonic anhydrase 2 (Car2), transcript variant 2, mRNA. / CA2* / P00918* / carbonic anhydrase 2*ENSMUSG0000002756221
Car13 / Q9D6N1 / Carbonic anhydrase 13 / CA13* / Q8N1Q1*ENSMUSG0000002755520
Car8 / P28651 / Carbonic anhydrase-related protein / CA8* / P35219* / carbonic anhydrase 8*ENSMUSG0000004126120
Car5b / Q9QZA0 / Carbonic anhydrase 5B, mitochondrial / CA5B* / Q9Y2D0* / carbonic anhydrase 5B*ENSMUSG0000003137319
Car1 / P13634 / Carbonic anhydrase 1 / CA1* / P00915*ENSMUSG0000002755619
Car3 / P16015 / Carbonic anhydrase 3 / CA3* / P07451*ENSMUSG0000002755919
Car5a / P23589 / Carbonic anhydrase 5A, mitochondrial / CA5A* / P35218* / carbonic anhydrase 5A*ENSMUSG0000002531718


Protein motifs (from Interpro)
Interpro ID Name
 IPR001148  Alpha carbonic anhydrase domain
 IPR018338  Carbonic anhydrase, alpha-class, conserved site
 IPR018429  Carbonic anhydrase 9
 IPR023561  Carbonic anhydrase, alpha-class
 IPR036398  Alpha carbonic anhydrase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002009 morphogenesis of an epithelium IMP
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0046903 secretion IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004089 carbonate dehydratase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Reversible hydration of carbon dioxide


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ap3b1pe-5J/?
Genetic Background: CBA/J-Ap3b1pe-5J

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002580 duodenal lesions "any pathological change in the structure of the wall of the duodenum" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
Show

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Car9tm1Spas/Car9tm1Spas
Genetic Background: B6.129P2-Car9tm1Spas

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9tm1Spas
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005493 stomach epithelial hyperplasia 
Show

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

Allelic Composition: Car9tm1Spas/Car9tm1Spas
Genetic Background: B6.129P2-Car9tm1Spas

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9tm1Spas
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Ace2tm1Lex/Y
Genetic Background: B6;129S5-Ace2tm1Lex/Mmucd

 MP:0010787 gastric cysts "abnormal membranous sacs in the wall of the stomach" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslgld/Faslgld
Genetic Background: C3H/HeJ-Faslgld/J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9tm1Spas
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0013567 gastric gland atrophy "acquired diminution of the size of any of the gastric glands, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal change" [MGI:Anna]
Show

Allelic Composition: Car9tm1Spas/Car9tm1Spas
Genetic Background: B6.129P2-Car9tm1Spas

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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