ENSMUSG00000041261


Mus musculus

Features
Gene ID: ENSMUSG00000041261
  
Biological name :Car8
  
Synonyms : Car8 / Carbonic anhydrase-related protein / P28651
  
Possible biological names infered from orthology : CA8 / carbonic anhydrase 8 / P35219
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A1
Gene start: 8143362
Gene end: 8239041
  
Corresponding Affymetrix probe sets: 10511429 (MoGene1.0st)   1424958_at (Mouse Genome 430 2.0 Array)   1427482_a_at (Mouse Genome 430 2.0 Array)   1457904_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063511
NCBI entrez gene - 12319     See in Manteia.
MGI - MGI:88253
RefSeq - NM_007592
RefSeq Peptide - NP_031618
swissprot - P28651
Ensembl - ENSMUSG00000041261
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ca8ENSDARG00000039098Danio rerio
 CA8ENSGALG00000039145Gallus gallus
 CA8ENSG00000178538Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Car7 / Q9ERQ8 / Carbonic anhydrase 7 / CA7* / P43166*ENSMUSG0000003188338
Car2 / P00920 / Mus musculus carbonic anhydrase 2 (Car2), transcript variant 2, mRNA. / CA2* / P00918* / carbonic anhydrase 2*ENSMUSG0000002756237
Car13 / Q9D6N1 / Carbonic anhydrase 13 / CA13* / Q8N1Q1*ENSMUSG0000002755536
Car1 / P13634 / Carbonic anhydrase 1 / CA1* / P00915*ENSMUSG0000002755636
Car5b / Q9QZA0 / Carbonic anhydrase 5B, mitochondrial / CA5B* / Q9Y2D0* / carbonic anhydrase 5B*ENSMUSG0000003137334
Car5a / P23589 / Carbonic anhydrase 5A, mitochondrial / CA5A* / P35218* / carbonic anhydrase 5A*ENSMUSG0000002531734
Car3 / P16015 / Carbonic anhydrase 3 / CA3* / P07451*ENSMUSG0000002755933
Car12 / carbonic anhydrase 12 / CA12* / O43570*ENSMUSG0000003237331
Car9 / Q8VHB5 / Carbonic anhydrase 9 / CA9* / Q16790*ENSMUSG0000002846330
Car15 / Q99N23 / Carbonic anhydrase 15 ENSMUSG0000009023627
Car14 / Q9WVT6 / Mus musculus carbonic anhydrase 14 (Car14), transcript variant 2, mRNA. / CA14* / Q9ULX7* / carbonic anhydrase 14*ENSMUSG0000003852627
Car6 / P18761 / Carbonic anhydrase 6 / CA6* / P23280*ENSMUSG0000002897227
Car4 / Q64444 / Carbonic anhydrase 4 / CA4* / P22748*ENSMUSG0000000080524


Protein motifs (from Interpro)
Interpro ID Name
 IPR001148  Alpha carbonic anhydrase domain
 IPR018338  Carbonic anhydrase, alpha-class, conserved site
 IPR023561  Carbonic anhydrase, alpha-class
 IPR036398  Alpha carbonic anhydrase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0004089 carbonate dehydratase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Dll1tm1Gos/Dll1tm1Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Dll1tm1Gos/Dll1tm1Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Dll1tm1Gos/Dll1tm1Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dll1tm1Gos/Dll1tm1Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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