ENSMUSG00000000805


Mus musculus

Features
Gene ID: ENSMUSG00000000805
  
Biological name :Car4
  
Synonyms : Car4 / Carbonic anhydrase 4 / Q64444
  
Possible biological names infered from orthology : CA4 / P22748
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 84957786
Gene end: 84966044
  
Corresponding Affymetrix probe sets: 10379866 (MoGene1.0st)   1418094_s_at (Mouse Genome 430 2.0 Array)   1448949_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099483
Ensembl peptide - ENSMUSP00000103711
Ensembl peptide - ENSMUSP00000115878
Ensembl peptide - ENSMUSP00000121381
NCBI entrez gene - 12351     See in Manteia.
MGI - MGI:1096574
RefSeq - XM_006532095
RefSeq - NM_007607
RefSeq Peptide - NP_031633
swissprot - D6RCZ3
swissprot - Q64444
swissprot - F6ST32
Ensembl - ENSMUSG00000000805
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ca15aENSDARG00000015654Danio rerio
 ca15bENSDARG00000040510Danio rerio
 ca15cENSDARG00000002259Danio rerio
 CA4 (1 of many)ENSDARG00000087756Danio rerio
 zgc:153760ENSDARG00000074666Danio rerio
 CA4ENSGALG00000005360Gallus gallus
 CA4ENSG00000167434Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Car15 / Q99N23 / Carbonic anhydrase 15 ENSMUSG0000009023634
Car14 / Q9WVT6 / Mus musculus carbonic anhydrase 14 (Car14), transcript variant 2, mRNA. / CA14* / Q9ULX7* / carbonic anhydrase 14*ENSMUSG0000003852631
Car12 / carbonic anhydrase 12 / CA12* / O43570*ENSMUSG0000003237330
Car9 / Q8VHB5 / Carbonic anhydrase 9 / CA9* / Q16790*ENSMUSG0000002846330
Car7 / Q9ERQ8 / Carbonic anhydrase 7 / CA7* / P43166*ENSMUSG0000003188328
Car13 / Q9D6N1 / Carbonic anhydrase 13 / CA13* / Q8N1Q1*ENSMUSG0000002755527
Car5b / Q9QZA0 / Carbonic anhydrase 5B, mitochondrial / CA5B* / Q9Y2D0* / carbonic anhydrase 5B*ENSMUSG0000003137326
Car2 / P00920 / Mus musculus carbonic anhydrase 2 (Car2), transcript variant 2, mRNA. / CA2* / P00918* / carbonic anhydrase 2*ENSMUSG0000002756226
Car6 / P18761 / Carbonic anhydrase 6 / CA6* / P23280*ENSMUSG0000002897225
Car3 / P16015 / Carbonic anhydrase 3 / CA3* / P07451*ENSMUSG0000002755924
Car1 / P13634 / Carbonic anhydrase 1 / CA1* / P00915*ENSMUSG0000002755624
Car5a / P23589 / Carbonic anhydrase 5A, mitochondrial / CA5A* / P35218* / carbonic anhydrase 5A*ENSMUSG0000002531724
Car8 / P28651 / Carbonic anhydrase-related protein / CA8* / P35219* / carbonic anhydrase 8*ENSMUSG0000004126123


Protein motifs (from Interpro)
Interpro ID Name
 IPR001148  Alpha carbonic anhydrase domain
 IPR018338  Carbonic anhydrase, alpha-class, conserved site
 IPR018343  Carbonic anhydrase, CA4
 IPR023561  Carbonic anhydrase, alpha-class
 IPR036398  Alpha carbonic anhydrase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0006885 regulation of pH IC
 biological_processGO:0015670 carbon dioxide transport IC
 biological_processGO:0015701 bicarbonate transport IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0030667 secretory granule membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0004089 carbonate dehydratase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mycntm1Jrt/Mycntm1Par
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mycntm1Jrt/Mycntm1Par
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004043 abnormal pH regulation "anomaly in the function of the buffer systems of the body in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the body, as measured by the concentration of hydrogen ion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Car14tm1Sly/Car14tm1Sly,Car4tm1Sly/Car4tm1Sly
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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