ENSMUSG00000029546


Mus musculus

Features
Gene ID: ENSMUSG00000029546
  
Biological name :Uncx
  
Synonyms : O08934 / UNC homeobox / Uncx
  
Possible biological names infered from orthology : A6NJT0
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 139543494
Gene end: 139548179
  
Corresponding Affymetrix probe sets: 10526956 (MoGene1.0st)   1419633_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134067
Ensembl peptide - ENSMUSP00000139081
NCBI entrez gene - 22255     See in Manteia.
MGI - MGI:108013
RefSeq - NM_013702
RefSeq Peptide - NP_038730
swissprot - O08934
swissprot - V9GXC0
Ensembl - ENSMUSG00000029546
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uncxENSDARG00000102976Danio rerio
 uncx4.1ENSDARG00000037760Danio rerio
 UNCXENSGALG00000039292Gallus gallus
 UNCXENSG00000164853Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arx / O35085 / Homeobox protein ARX / Q96QS3* / aristaless related homeobox*ENSMUSG0000003527719
Alx3 / O70137 / Homeobox protein aristaless-like 3 / O95076* / ALX homeobox 3*ENSMUSG0000001460317
Alx4 / O35137 / Homeobox protein aristaless-like 4 / Q9H161* / ALX homeobox 4*ENSMUSG0000004031017
Rax / O35602 / Retinal homeobox protein Rx / Q9Y2V3* / retina and anterior neural fold homeobox*ENSMUSG0000002451815
O35690 / Phox2b / Paired mesoderm homeobox protein 2B / Q99453* / paired like homeobox 2b*ENSMUSG0000001252015
Vsx1 / Q91V10 / visual system homeobox 1 / Q9NZR4*ENSMUSG0000003308015
Phox2a / Q62066 / Paired mesoderm homeobox protein 2A / O14813* / paired like homeobox 2a*ENSMUSG0000000794615
Prrxl1 / Q8BYH0 / paired related homeobox protein-like 1 / DRGX* / A6NNA5* / dorsal root ganglia homeobox*ENSMUSG0000004173014
Vsx2 / Q61412 / visual system homeobox 2 / P58304*ENSMUSG0000002123914
Alx1 / Q8C8B0 / ALX homeobox protein 1 / Q15699* / ALX homeobox 1*ENSMUSG0000003660214
Isx / A1A546 / intestine specific homeobox / Q2M1V0*ENSMUSG0000003162112


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001502 cartilage condensation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007389 pattern specification process IMP
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0021516 dorsal spinal cord development IMP
 biological_processGO:0021889 olfactory bulb interneuron differentiation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035726 common myeloid progenitor cell proliferation IMP
 biological_processGO:0045595 regulation of cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0000139 absent transverse processes "loss of bony protrusion of either side of the arch of a thoracic vertebrae" [J:62022, J:62023]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0000140 absent pedicles "loss of part of the posteriorlateral vertebral arch of a thoracic vertebrae" [J:62022, J:62023]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0000152 absent proximal rib "missing part of rib structures near the spine, ribs do not contact vertebrae" [J:62022, J:62023]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000962 disorganized dorsal root ganglia "loss of segmentation pattern of DRGs; loss of regular spacing " [J:62022, J:62023]
Show

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0000963 fused dorsal root ganglia "loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0004612 fusion of vertebral bodies "improper union of the main cylindrical portion of adjacent vertebra ventral to the vertebral canal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0004734 small thoracic cavity "reduced size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0006029 abnormal sclerotome "malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

 MP:0008147 asymmetric rib-vertebral column attachment "loss of bilateral symmetry in rib attachments to the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Tubtm1Rok/Tubtm1Rok
Genetic Background: C57BL/6-Tubtm1Rok

Allelic Composition: Uncxtm1Pgr/Uncxtm1Pgr
Genetic Background: involves: NMRI

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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