Manteia

ENSMUSG00000024518

Mus musculus

Features

Gene ID:	ENSMUSG00000024518

Biological name :	Rax

Synonyms :	O35602 / Rax / Retinal homeobox protein Rx

Possible biological names infered from orthology :	Q9Y2V3 / retina and anterior neural fold homeobox

Species:	Mus musculus

Chr. number:	18
Strand:	-1
Band:	E1
Gene start:	65934639
Gene end:	65939089

Corresponding Affymetrix probe sets:	10459471 (MoGene1.0st) 1418558_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000025396 NCBI entrez gene - 19434 See in Manteia. MGI - MGI:109632 RefSeq - NM_013833 RefSeq Peptide - NP_038861 swissprot - O35602 Ensembl - ENSMUSG00000024518

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rx3	ENSDARG00000052893	Danio rerio
RAX	ENSGALG00000033279	Gallus gallus
RAX	ENSG00000134438	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Arx / O35085 / Homeobox protein ARX / Q96QS3* / aristaless related homeobox*	ENSMUSG00000035277	30
Alx4 / O35137 / Homeobox protein aristaless-like 4 / Q9H161* / ALX homeobox 4*	ENSMUSG00000040310	27
Vsx2 / Q61412 / visual system homeobox 2 / P58304*	ENSMUSG00000021239	25
Uncx / O08934 / UNC homeobox / A6NJT0*	ENSMUSG00000029546	24
Alx3 / O70137 / Homeobox protein aristaless-like 3 / O95076* / ALX homeobox 3*	ENSMUSG00000014603	23
Alx1 / Q8C8B0 / ALX homeobox protein 1 / Q15699* / ALX homeobox 1*	ENSMUSG00000036602	23
Vsx1 / Q91V10 / visual system homeobox 1 / Q9NZR4*	ENSMUSG00000033080	21
Prrxl1 / Q8BYH0 / paired related homeobox protein-like 1 / DRGX* / A6NNA5* / dorsal root ganglia homeobox*	ENSMUSG00000041730	20
Phox2a / Q62066 / Paired mesoderm homeobox protein 2A / O14813* / paired like homeobox 2a*	ENSMUSG00000007946	20
Isx / A1A546 / intestine specific homeobox / Q2M1V0*	ENSMUSG00000031621	19
O35690 / Phox2b / Paired mesoderm homeobox protein 2B / Q99453* / paired like homeobox 2b*	ENSMUSG00000012520	19

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR003654	OAR domain
IPR009057	Homeobox-like domain superfamily
IPR017970	Homeobox, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007389	pattern specification process	IMP
biological_process	GO:0007420	brain development	IMP
biological_process	GO:0021854	hypothalamus development	IMP
biological_process	GO:0043010	camera-type eye development	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0060173	limb development	IMP
cellular_component	GO:0005634	nucleus	IEA
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Rax^tm1.2Lwd/Rax^tm1.2Lwd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J
MP:0000837	abnormal hypothalamus morphology	"any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Smpd3^fro/Smpd3^fro Genetic Background: C3H.Cg-Smpd3^fro
MP:0001286	abnormal eye development	"malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Rax^tm1Lwd/Rax^tm1Lwd Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Rax^tm1.2Lwd/Rax^tm1.2Lwd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001293	anophthalmia	"congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Rax^tm1Lwd/Rax^tm1Lwd Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Rax^tm1.2Lwd/Rax^tm1.2Lwd Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Rax^tm1.1Lwd/Rax^tm1.1Lwd,Tg(rx3-icre)1Mjam/0 Genetic Background: involves: 129S1/Sv Allelic Composition: Rax^ey1/Rax^ey1 Genetic Background: ZRDCT/Ch-Rax^ey1 Allelic Composition: Rax^ey1/Rax^ey1 Genetic Background: involves: ZRDCT/Ch Allelic Composition: Rax^{tm1.1(rTA,tetO-cre)Lan}/? Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Rax^ey1/Rax^ey1 Genetic Background: ZRDCT/Ch-Rax^ey1 Allelic Composition: Rax^{tm1.1(rTA,tetO-cre)Lan}/? Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Myd88^tm1Defr/Myd88^tm1Defr,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
MP:0001306	small lens	"reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Myd88^tm1Defr/Myd88^tm1Defr,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
MP:0001330	abnormal optic nerve morphology	"malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rax^ey1/Rax^ey1 Genetic Background: involves: ZRDCT/Ch
MP:0002081	perinatal lethality	"death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Rax^tm1Lwd/Rax^tm1Lwd Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Rax^tm1.2Lwd/Rax^tm1.2Lwd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rax^ey1/Rax^ey1 Genetic Background: ZRDCT/Ch-Rax^ey1 Allelic Composition: ey2/ey2⁺,Rax^ey1/Rax⁺ Genetic Background: involves: ZRDCT/Ch
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rax^tm1Lwd/Rax^tm1Lwd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002621	delayed neural tube closure	"delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Rax^tm1Lwd/Rax^tm1Lwd Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Rax^tm1.2Lwd/Rax^tm1.2Lwd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002984	retina hypoplasia	"less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994]	Show Allelic Composition: Lhx2^tm1.1Lcar/Lhx2^tm1.1Lcar,Tg(Lhx2-cre)1Lcar/0 Genetic Background: involves: 129P2/OlaHsd
MP:0003755	abnormal palate	"anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J
MP:0004269	abnormal optic cup morphology	"any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Rax^ey1/Rax^ey1 Genetic Background: ZRDCT/Ch-Rax^ey1
MP:0005545	abnormal lens development	"aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rax^ey1/Rax^ey1 Genetic Background: ZRDCT/Ch-Rax^ey1
MP:0006294	absent optic vesicle	"absence of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [J:94391, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J
MP:0008847	abnormal suprachiasmatic nucleus morphology	"any structural anomaly of an ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the optic chiasm; it receives input from the retina and influences neuroendocrine function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.317.357.342.625]	Show Allelic Composition: Rax^ey1/Rax^ey1 Genetic Background: involves: ZRDCT/Ch
MP:0011255	abnormal anterior visceral endoderm cell migration	"any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:csmith, PMID:17078044]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J
MP:0012089	decreased midbrain size	"size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J
MP:0012136	absent forebrain	"absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J
MP:0020476	abnormal circardian behavior entrainment	"anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]	Show Allelic Composition: Rax^ey1/Rax^ey1 Genetic Background: ZRDCT/Ch-Rax^ey1
MP:0030241	absent optic pit	"absence of either or both of the two pits that appear bilaterally in the region destined to become the forebrain as the cranial neural folds fuse; these optic pits or sulci continue to deepen laterally and bulge from the two sides of the forebrain to become the optic vesicles" [MGI:anna]	Show Allelic Composition: Abcc6^{Dyscalc1-DBA/2J}/Abcc6^{Dyscalc1-DBA/2J} Genetic Background: involves: C57BL/6J * DBA/2J Allelic Composition: Rax^tm1Lwd/Rax^tm1Lwd Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Rax^tm1.2Lwd/Rax^tm1.2Lwd Genetic Background: involves: 129S1/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr