ENSMUSG00000031621


Mus musculus

Features
Gene ID: ENSMUSG00000031621
  
Biological name :Isx
  
Synonyms : A1A546 / intestine specific homeobox / Isx
  
Possible biological names infered from orthology : Q2M1V0
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C1
Gene start: 74873173
Gene end: 74893506
  
Corresponding Affymetrix probe sets: 10572865 (MoGene1.0st)   1431922_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034034
Ensembl peptide - ENSMUSP00000134368
NCBI entrez gene - 71597     See in Manteia.
MGI - MGI:1918847
RefSeq - NM_001294278
RefSeq - NM_027837
RefSeq Peptide - NP_001281207
RefSeq Peptide - NP_082113
swissprot - B1Q2M1
swissprot - A1A546
Ensembl - ENSMUSG00000031621
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ISXENSGALG00000012557Gallus gallus
 ISXENSG00000175329Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arx / O35085 / Homeobox protein ARX / Q96QS3* / aristaless related homeobox*ENSMUSG0000003527728
Alx3 / O70137 / Homeobox protein aristaless-like 3 / O95076* / ALX homeobox 3*ENSMUSG0000001460328
Rax / O35602 / Retinal homeobox protein Rx / Q9Y2V3* / retina and anterior neural fold homeobox*ENSMUSG0000002451827
Uncx / O08934 / UNC homeobox / A6NJT0*ENSMUSG0000002954627
Alx1 / Q8C8B0 / ALX homeobox protein 1 / Q15699* / ALX homeobox 1*ENSMUSG0000003660226
O35690 / Phox2b / Paired mesoderm homeobox protein 2B / Q99453* / paired like homeobox 2b*ENSMUSG0000001252026
Alx4 / O35137 / Homeobox protein aristaless-like 4 / Q9H161* / ALX homeobox 4*ENSMUSG0000004031026
Phox2a / Q62066 / Paired mesoderm homeobox protein 2A / O14813* / paired like homeobox 2a*ENSMUSG0000000794626
Vsx1 / Q91V10 / visual system homeobox 1 / Q9NZR4*ENSMUSG0000003308025
Vsx2 / Q61412 / visual system homeobox 2 / P58304*ENSMUSG0000002123924
Prrxl1 / Q8BYH0 / paired related homeobox protein-like 1 / DRGX* / A6NNA5* / dorsal root ganglia homeobox*ENSMUSG0000004173023


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:1901738 regulation of vitamin A metabolic process IMP
 biological_processGO:1904479 negative regulation of intestinal absorption IMP
 cellular_componentGO:0005634 nucleus IC
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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