ENSMUSG00000041730


Mus musculus

Features
Gene ID: ENSMUSG00000041730
  
Biological name :Prrxl1
  
Synonyms : paired related homeobox protein-like 1 / Prrxl1 / Q8BYH0
  
Possible biological names infered from orthology : A6NNA5 / dorsal root ganglia homeobox / DRGX
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 32599407
Gene end: 32649246
  
Corresponding Affymetrix probe sets: 10413919 (MoGene1.0st)   1439193_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139756
Ensembl peptide - ENSMUSP00000140687
Ensembl peptide - ENSMUSP00000154801
Ensembl peptide - ENSMUSP00000064107
Ensembl peptide - ENSMUSP00000140337
NCBI entrez gene - 107751     See in Manteia.
MGI - MGI:2148204
RefSeq - XM_011244909
RefSeq - NM_001001796
RefSeq - NM_001347590
RefSeq - XM_006518411
RefSeq - XM_006518412
RefSeq - XM_006518413
RefSeq - XM_006518414
RefSeq - XM_006518409
RefSeq - XM_006518410
RefSeq Peptide - NP_001001796
RefSeq Peptide - NP_001334519
swissprot - Q8BYH0
swissprot - B7ZW86
Ensembl - ENSMUSG00000041730
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 drgxENSDARG00000069329Danio rerio
 DRGXENSGALG00000030822Gallus gallus
 DRGXENSG00000165606Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arx / O35085 / Homeobox protein ARX / Q96QS3* / aristaless related homeobox*ENSMUSG0000003527733
Alx4 / O35137 / Homeobox protein aristaless-like 4 / Q9H161* / ALX homeobox 4*ENSMUSG0000004031030
Alx3 / O70137 / Homeobox protein aristaless-like 3 / O95076* / ALX homeobox 3*ENSMUSG0000001460329
Alx1 / Q8C8B0 / ALX homeobox protein 1 / Q15699* / ALX homeobox 1*ENSMUSG0000003660228
O35690 / Phox2b / Paired mesoderm homeobox protein 2B / Q99453* / paired like homeobox 2b*ENSMUSG0000001252028
Phox2a / Q62066 / Paired mesoderm homeobox protein 2A / O14813* / paired like homeobox 2a*ENSMUSG0000000794628
Rax / O35602 / Retinal homeobox protein Rx / Q9Y2V3* / retina and anterior neural fold homeobox*ENSMUSG0000002451827
Vsx2 / Q61412 / visual system homeobox 2 / P58304*ENSMUSG0000002123927
Uncx / O08934 / UNC homeobox / A6NJT0*ENSMUSG0000002954627
Vsx1 / Q91V10 / visual system homeobox 1 / Q9NZR4*ENSMUSG0000003308022
Isx / A1A546 / intestine specific homeobox / Q2M1V0*ENSMUSG0000003162121


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0009593 detection of chemical stimulus IMP
 biological_processGO:0016048 detection of temperature stimulus IMP
 biological_processGO:0021516 dorsal spinal cord development IMP
 biological_processGO:0021559 trigeminal nerve development IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0050954 sensory perception of mechanical stimulus IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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