| MP:0000189 | hypoglycemia | "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6
|
| MP:0000243 | myoclonus | "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Arxtm1.1Jno/Arxtm1.1Jno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
|
| MP:0000746 | weakness | "state of being infirm or less strong than littermates" [J:45400] |
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6
|
| MP:0000774 | reduced brain size | "smaller appearance of the brain" [J:35802] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
Allelic Composition: Arxtm1Gldn/Y,Tg(Pou3f4-cre)32Cren/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1
Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0000778 | abnormal tract | |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
|
| MP:0000780 | abnormal corpus callosum morphology | "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
|
| MP:0000787 | abnormal telencephalon morphology | "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
|
| MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Arxtm1Gldn/Y,Tg(Pou3f4-cre)32Cren/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1
Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
|
| MP:0000792 | abnormal cortical marginal zone morphology | |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
|
| MP:0000808 | abnormal hippocampus development | "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
|
| MP:0000812 | abnormal dentate gyrus morphology | "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
|
| MP:0000819 | abnormal olfactory bulb morphology | "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
Allelic Composition: Arxtm1Gldn/Y,Tg(Pou3f4-cre)32Cren/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1
|
| MP:0000832 | abnormal thalamus morphology | "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
|
| MP:0000859 | abnormal somatosensory cortex morphology | "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
|
| MP:0000934 | abnormal telencephalon development | "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
|
| MP:0000947 | convulsive seizures | "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * 129S4/SvJae * C3H/HeH * C57BL/6
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| MP:0000951 | sporadic seizures | "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * 129S4/SvJae * C3H/HeH * C57BL/6
Allelic Composition: Arxtm1Gldn/Arx+,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 * FVB/N
|
| MP:0001038 | abnormal cholinergic neuron morphology | "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0001147 | small testis | "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
|
| MP:0001363 | increased anxiety-related response | "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060] |
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Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0001364 | decreased anxiety-related response | "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pax7tm1.1Fan/Pax7tm2.1(cre/ERT2)Fan
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0001429 | dehydration | "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053] |
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6
|
| MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0001559 | hyperglycemia | "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * C57BL/6J * SJL
|
| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6
|
| MP:0002062 | abnormal conditioning behavior | "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pax7tm1.1Fan/Pax7tm2.1(cre/ERT2)Fan
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0002064 | seizures | "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pax7tm1.1Fan/Pax7tm2.1(cre/ERT2)Fan
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Igkctm1Bgmn/Igkctm1Bgmn,Igltm2.1Bgmn/Igltm2.1Bgmn
Genetic Background: involves: 129
Allelic Composition: Arxtm1Gldn/Arxtm1Gldn
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0002741 | small olfactory bulb | "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871] |
Show
Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0002826 | tonic seizures | "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0002906 | susceptibility to pharmacologically induced seizures | "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504] |
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Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0003232 | abnormal forebrain development | "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0003246 | loss of GABA neurons | "loss of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] |
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Allelic Composition: Arxtm3Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0003247 | abnormal glutaminergic neuron | "malformation or absence of the neurons that utilize glutamate as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0003339 | decreased number of pancreatic beta cells | "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Arxtm1Gldn/Arxtm1Gldn,Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * CBA/J * SJL
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| MP:0003645 | increased number of pancreatic beta cells | "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0003858 | enhanced coordination | "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
|
| MP:0003863 | decreased aggression towards mice | "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
|
| MP:0003996 | clonic seizures | "increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * 129S4/SvJae * C3H/HeH * C57BL/6
Allelic Composition: Arxtm1Gldn/Arx+,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 * FVB/N
Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0003997 | tonic-clonic seizures | "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * 129S4/SvJae * C3H/HeH * C57BL/6
Allelic Composition: Arxtm1Gldn/Arx+,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 * FVB/N
Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0003998 | decreased thermal nociceptive threshold | "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0004000 | impaired passive avoidance behavior | "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Arxtm3Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0004077 | abnormal striatum morphology | "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
Show
Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0004101 | abnormal brain interneuron morphology | "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * 129S4/SvJae * C3H/HeH * C57BL/6
Allelic Composition: Arxtm1Gldn/Arx+,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 * FVB/N
Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Arxtm5Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0004103 | abnormal ventral striatum morphology | "any structural abnormality of the regions of the nucleus accumbens and some nuclei of the olfactory tubercule that lie ventral to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0004275 | abnormal postnatal subventricular zone morphology | "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172] |
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Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0004994 | abnormal brain wave pattern | "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * 129S4/SvJae * C3H/HeH * C57BL/6
Allelic Composition: Arxtm1Gldn/Arx+,Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1 * FVB/N
Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
|
| MP:0005148 | seminal gland hypoplasia | "reduction in size, usually due to a reduction in cell number, of one of the two folded, sac shaped glands that is a diverticulum of the ductus deferens" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64337] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0005218 | abnormal pancreatic delta cell morphology | "malformation of the cells found in the pancreas and gastrointestinal tract that secrete somatostatin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0006009 | abnormal neuronal migration | "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Arxtm3Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0006308 | enlarged seminiferous tubules | "increased diameter of the tubules in the testes where spermatogenesis occurs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0008128 | abnormal brain internal capsule morphology | "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0008223 | absent hippocampal commissure | "absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0008267 | abnormal hippocampus CA3 region morphology | |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0008269 | abnormal hippocampus CA4 region morphology | |
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Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0008439 | abnormal cortical plate morphology | "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0008441 | thin cortical plate | "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0008458 | abnormal cortical ventricular zone morphology | "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0008536 | enlarged third ventricle | "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0008547 | abnormal neocortex morphology | "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * 129S4/SvJae * C3H/HeH * C57BL/6
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| MP:0008840 | abnormal spike wave discharge | "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200] |
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Allelic Composition: Arxtm4Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0008929 | abnormal central medial nucleus morphology | "any structural anomaly of a small cell group in the interthalamic adhesion of the thalamus that occupy the midline region of the internal medullary lamina, between the left and right paracentral nuclei" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0009178 | absent pancreatic alpha cells | "absence of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065] |
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0009180 | increased pancreatic delta cell number | "increased number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854] |
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0009324 | absent hippocampal fimbria | "absence of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which eventually thickens to form the fornix and fibers of the hippocampal commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.464.265, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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| MP:0009454 | impaired contextual conditioning | "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0009456 | impaired cued conditioning behavior | "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Arxtm1.1Jno/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Arxtm3Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * 129S4/SvJae * C3H/HeH * C57BL/6
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
Allelic Composition: Arxtm2Kki/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0013603 | abnormal fetal Leydig cell differentiation | "atypical formation of or inability to produce the first or fetal population of Leydig cells (FLCs); in mice, FLCs arise in the testicular interstitium between E12.5 and E13.0, approximately 1 day after the appearance of Sertoli cells; Sertoli cells trigger differentiation of steroidogenic factor 1-positive (SF1-positive) progenitor cells into FLCs via paracrine regulation; the intercellular Notch signaling pathway is also involved in FLC establishment and maintenance; the FLC population increases dramatically during embryonic development despite the fact that differentiating FLCs are mitotically inactive, suggesting that expansion of FLC populations results from differentiation of progenitor cells, rather than cell division of existing FLCs; the SF1-positive cells in gonadal primordia are the primary source of FLCs but other sources such as neighboring mesonephros, migrating neural crest cells, and cells from the coelomic epithelium or interstitium are potential contributors also; at the end of fetal life and during the first 2 postnatal weeks in rodents, FLCs are gradually replaced by adult Leydig cells (ALCs)" [PMID:23568777] |
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ
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