ENSMUSG00000007946


Mus musculus

Features
Gene ID: ENSMUSG00000007946
  
Biological name :Phox2a
  
Synonyms : Paired mesoderm homeobox protein 2A / Phox2a / Q62066
  
Possible biological names infered from orthology : O14813 / paired like homeobox 2a
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E2
Gene start: 101818313
Gene end: 101822726
  
Corresponding Affymetrix probe sets: 10555570 (MoGene1.0st)   1418620_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008090
NCBI entrez gene - 11859     See in Manteia.
MGI - MGI:106633
RefSeq - NM_008887
RefSeq Peptide - NP_032913
swissprot - Q62066
Ensembl - ENSMUSG00000007946
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phox2aENSDARG00000007406Danio rerio
 O14813ENSG00000165462Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35690 / Phox2b / Paired mesoderm homeobox protein 2B / Q99453* / paired like homeobox 2b*ENSMUSG0000001252058
Arx / O35085 / Homeobox protein ARX / Q96QS3* / aristaless related homeobox*ENSMUSG0000003527731
Alx4 / O35137 / Homeobox protein aristaless-like 4 / Q9H161* / ALX homeobox 4*ENSMUSG0000004031029
Alx3 / O70137 / Homeobox protein aristaless-like 3 / O95076* / ALX homeobox 3*ENSMUSG0000001460329
Uncx / O08934 / UNC homeobox / A6NJT0*ENSMUSG0000002954628
Alx1 / Q8C8B0 / ALX homeobox protein 1 / Q15699* / ALX homeobox 1*ENSMUSG0000003660228
Prrxl1 / Q8BYH0 / paired related homeobox protein-like 1 / DRGX* / A6NNA5* / dorsal root ganglia homeobox*ENSMUSG0000004173026
Rax / O35602 / Retinal homeobox protein Rx / Q9Y2V3* / retina and anterior neural fold homeobox*ENSMUSG0000002451825
Isx / A1A546 / intestine specific homeobox / Q2M1V0*ENSMUSG0000003162123
Vsx2 / Q61412 / visual system homeobox 2 / P58304*ENSMUSG0000002123923
Vsx1 / Q91V10 / visual system homeobox 1 / Q9NZR4*ENSMUSG0000003308023


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003357 noradrenergic neuron differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0021523 somatic motor neuron differentiation IMP
 biological_processGO:0021623 oculomotor nerve formation IMP
 biological_processGO:0021642 trochlear nerve formation IMP
 biological_processGO:0021703 locus ceruleus development IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0043576 regulation of respiratory gaseous exchange IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048485 sympathetic nervous system development IMP
 biological_processGO:0048486 parasympathetic nervous system development IMP
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Lmx1atm1Ics/Lmx1atm1Ics,Lmx1btm1Rjo/Lmx1b+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001034 abnormal parasympathetic ganglia morphology "malformation or absence of the ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001035 abnormal submandibular ganglion morphology "malformation or absence of the ganglion associated with the lingual nerve" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001036 small submandibular ganglion "reduced size of the small parasympathetic ganglion of the lingual nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53284]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001061 abnormal oculomotor nerve morphology "malformation or misprojection of the 3rd cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye; and also sends parasympathetic efferents to the muscles controlling pupillary constriction and accommodation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
Genetic Background: involves: 129S4/SvJae

 MP:0001063 abnormal trochlear nerve morphology "any malformation or misprojection of the 4th cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
Genetic Background: involves: 129S4/SvJae

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001083 small geniculate ganglion "reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001085 small petrosal ganglion "reduced size of the petrosal ganglion" [J:25565]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001088 small nodose ganglion "reduced size of the nodose ganglion" [J:25565, J:17123]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129 * BALB/c

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0002751 abnormal autonomic nervous system morphology "any malformation or absence of neurons in the motor system for the viscera, the smooth muscles of the body or exocrine glands; includes the enteric, parasympathetic, and sympathetic nervous systems taken together" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0003661 abnormal locus ceruleus "anomaly in a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic" [J:96328, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129 * BALB/c

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae
Genetic Background: involves: 129 * BALB/c

 MP:0005573 increased breathing frequency "greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005574 decreased breathing frequency "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0005575 increased pulmonary ventilation "greater than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005585 increased tidal volume "greater than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008314 abnormal pterygopalatine ganglion morphology "any structural anomaly of the small parasympathetic ganglion that supplies nerve fibers to the lacrimal, nasal, palatine and pharyngeal glands" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008315 abnormal otic ganglion morphology "any structural anomaly of the ganglion that supplies nerve fibers to the parotid gland" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Lmx1atm1Ics/Lmx1atm1Ics,Lmx1btm1Rjo/Lmx1b+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmx1atm1Ics/Lmx1atm1Ics,Lmx1btm1Rjo/Lmx1b+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010105 abnormal sublingual ganglion morphology "any structural anomaly of the small parasympathetic ganglion found anterior to the submandibular gland that provides postsynaptic fibers to the sublingual gland" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Kdrtm1Jrt/Kdrtm1Jrt
Genetic Background: B6.129-Kdrtm1Jrt/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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