ENSMUSG00000034472


Mus musculus

Features
Gene ID: ENSMUSG00000034472
  
Biological name :Rasd2
  
Synonyms : GTP-binding protein Rhes / P63032 / Rasd2
  
Possible biological names infered from orthology : Q96D21 / RASD family member 2
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C1
Gene start: 75213944
Gene end: 75224113
  
Corresponding Affymetrix probe sets: 10572928 (MoGene1.0st)   1427343_at (Mouse Genome 430 2.0 Array)   1427344_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118070
Ensembl peptide - ENSMUSP00000120717
NCBI entrez gene - 75141     See in Manteia.
MGI - MGI:1922391
RefSeq - NM_029182
RefSeq Peptide - NP_083458
swissprot - P63032
Ensembl - ENSMUSG00000034472
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RASD2ENSGALG00000012542Gallus gallus
 RASD2ENSG00000100302Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rasd1 / O35626 / Dexamethasone-induced Ras-related protein 1 / Q9Y272* / ras related dexamethasone induced 1*ENSMUSG0000004989262
Diras2 / Q5PR73 / GTP-binding protein Di-Ras2 / Q96HU8* / DIRAS family GTPase 2*ENSMUSG0000004784229
Diras1 / Q91Z61 / GTP-binding protein Di-Ras1 / O95057* / DIRAS family GTPase 1*ENSMUSG0000004367029
Rit2 / P70425 / GTP-binding protein Rit2 / Q99578* / Ras like without CAAX 2*ENSMUSG0000005745526
Rap2a / Q80ZJ1 / Ras-related protein Rap-2a / P10114* / RAP2A, member of RAS oncogene family*ENSMUSG0000005161526
Rit1 / P70426 / GTP-binding protein Rit1 / Q92963* / Ras like without CAAX 1*ENSMUSG0000002805726
Rap2b / P61226 / RAP2B, member of RAS oncogene family / P61225*ENSMUSG0000003689426
Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*ENSMUSG0000006879826
Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*ENSMUSG0000005268126
Rap2c / Q8BU31 / Ras-related protein Rap-2c / Q9Y3L5* / RAP2C, member of RAS oncogene family*ENSMUSG0000005002925
Q8K5A4 / Rasl10a / Ras-like protein family member 10A / Q92737* / RAS like family 10 member A*ENSMUSG0000003420923
Q5SSG5 / Rasl10b / Ras-like protein family member 10B / Q96S79* / RAS like family 10 member B*ENSMUSG0000002068421
Gm266ENSMUSG0000001052919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001963 synaptic transmission, dopaminergic IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007610 behavior IEA
 biological_processGO:0007626 locomotory behavior IDA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0033235 positive regulation of protein sumoylation IEA
 biological_processGO:0043949 regulation of cAMP-mediated signaling ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IEA
 molecular_functionGO:0031681 G-protein beta-subunit binding ISO
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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