Manteia

ENSMUSG00000036894

Mus musculus

Features

Gene ID:	ENSMUSG00000036894

Biological name :	Rap2b

Synonyms :	P61226 / Rap2b / RAP2B, member of RAS oncogene family

Possible biological names infered from orthology :	P61225

Species:	Mus musculus

Chr. number:	3
Strand:	1
Band:	E1
Gene start:	61361638
Gene end:	61368430

Corresponding Affymetrix probe sets:	10492335 (MoGene1.0st) 1417914_at (Mouse Genome 430 2.0 Array) 1417915_at (Mouse Genome 430 2.0 Array) 1439548_at (Mouse Genome 430 2.0 Array) 1448885_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000038841 NCBI entrez gene - 74012 See in Manteia. MGI - MGI:1921262 RefSeq - NM_028712 RefSeq Peptide - NP_082988 swissprot - P61226 swissprot - Q6ZWR0 Ensembl - ENSMUSG00000036894

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Rap2a / Q80ZJ1 / Ras-related protein Rap-2a / P10114* / RAP2A, member of RAS oncogene family*	ENSMUSG00000051615	91
Rap2c / Q8BU31 / Ras-related protein Rap-2c / Q9Y3L5* / RAP2C, member of RAS oncogene family*	ENSMUSG00000050029	86
Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*	ENSMUSG00000068798	62
Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*	ENSMUSG00000052681	61
Rit1 / P70426 / GTP-binding protein Rit1 / Q92963* / Ras like without CAAX 1*	ENSMUSG00000028057	45
Diras2 / Q5PR73 / GTP-binding protein Di-Ras2 / Q96HU8* / DIRAS family GTPase 2*	ENSMUSG00000047842	45
Diras1 / Q91Z61 / GTP-binding protein Di-Ras1 / O95057* / DIRAS family GTPase 1*	ENSMUSG00000043670	44
Gm266	ENSMUSG00000010529	43
Rit2 / P70425 / GTP-binding protein Rit2 / Q99578* / Ras like without CAAX 2*	ENSMUSG00000057455	43
Rasd1 / O35626 / Dexamethasone-induced Ras-related protein 1 / Q9Y272* / ras related dexamethasone induced 1*	ENSMUSG00000049892	39
Rasd2 / P63032 / GTP-binding protein Rhes / Q96D21* / RASD family member 2*	ENSMUSG00000034472	37
Q5SSG5 / Rasl10b / Ras-like protein family member 10B / Q96S79* / RAS like family 10 member B*	ENSMUSG00000020684	31
Q8K5A4 / Rasl10a / Ras-like protein family member 10A / Q92737* / RAS like family 10 member A*	ENSMUSG00000034209	30

Protein motifs (from Interpro)

Interpro ID	Name
IPR001806	Small GTPase superfamily
IPR005225	Small GTP-binding protein domain
IPR020849	Small GTPase superfamily, Ras-type
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0030168	platelet activation	IEA
biological_process	GO:0030336	negative regulation of cell migration	IDA
biological_process	GO:0031954	positive regulation of protein autophosphorylation	IDA
biological_process	GO:0032486	Rap protein signal transduction	IDA
biological_process	GO:0061097	regulation of protein tyrosine kinase activity	IDA
biological_process	GO:0070527	platelet aggregation	IEA
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005923	bicellular tight junction	IEA
cellular_component	GO:0016020	membrane	ISO
cellular_component	GO:0044291	cell-cell contact zone	IEA
cellular_component	GO:0045121	membrane raft	IEA
cellular_component	GO:0055037	recycling endosome	IDA
cellular_component	GO:0055038	recycling endosome membrane	IEA
cellular_component	GO:0070062	extracellular exosome	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003924	GTPase activity	IEA
molecular_function	GO:0005525	GTP binding	ISO
molecular_function	GO:0019003	GDP binding	IEA
molecular_function	GO:0019904	protein domain specific binding	IPI

Pathways (from Reactome)

Pathway description

Neutrophil degranulation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ptpn12^{tm1b(NCOM)Mfgc}/Ptpn12^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Ptpn12^{tm1b(NCOM)Mfgc}/Tcp
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Ptpn12^{tm1b(NCOM)Mfgc}/Ptpn12^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Ptpn12^{tm1b(NCOM)Mfgc}/Tcp
MP:0003898	abnormal QRS complex	"anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Ptpn12^{tm1b(NCOM)Mfgc}/Ptpn12^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Ptpn12^{tm1b(NCOM)Mfgc}/Tcp
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptpn12^{tm1b(NCOM)Mfgc}/Ptpn12^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Ptpn12^{tm1b(NCOM)Mfgc}/Tcp

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr