ENSMUSG00000049892


Mus musculus

Features
Gene ID: ENSMUSG00000049892
  
Biological name :Rasd1
  
Synonyms : Dexamethasone-induced Ras-related protein 1 / O35626 / Rasd1
  
Possible biological names infered from orthology : Q9Y272 / ras related dexamethasone induced 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 59963181
Gene end: 59964944
  
Corresponding Affymetrix probe sets: 10386455 (MoGene1.0st)   1423619_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051959
NCBI entrez gene - 19416     See in Manteia.
MGI - MGI:1270848
RefSeq - NM_009026
RefSeq Peptide - NP_033052
swissprot - O35626
swissprot - Q5SWR8
Ensembl - ENSMUSG00000049892
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasd1ENSDARG00000019274Danio rerio
 RASD1ENSGALG00000004860Gallus gallus
 RASD1ENSG00000108551Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rasd2 / P63032 / GTP-binding protein Rhes / Q96D21* / RASD family member 2*ENSMUSG0000003447259
Diras1 / Q91Z61 / GTP-binding protein Di-Ras1 / O95057* / DIRAS family GTPase 1*ENSMUSG0000004367026
Rit2 / P70425 / GTP-binding protein Rit2 / Q99578* / Ras like without CAAX 2*ENSMUSG0000005745525
Rap2a / Q80ZJ1 / Ras-related protein Rap-2a / P10114* / RAP2A, member of RAS oncogene family*ENSMUSG0000005161525
Rap2c / Q8BU31 / Ras-related protein Rap-2c / Q9Y3L5* / RAP2C, member of RAS oncogene family*ENSMUSG0000005002925
Rap2b / P61226 / RAP2B, member of RAS oncogene family / P61225*ENSMUSG0000003689425
Diras2 / Q5PR73 / GTP-binding protein Di-Ras2 / Q96HU8* / DIRAS family GTPase 2*ENSMUSG0000004784225
Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*ENSMUSG0000006879824
Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*ENSMUSG0000005268124
Rit1 / P70426 / GTP-binding protein Rit1 / Q92963* / Ras like without CAAX 1*ENSMUSG0000002805724
Q8K5A4 / Rasl10a / Ras-like protein family member 10A / Q92737* / RAS like family 10 member A*ENSMUSG0000003420922
Q5SSG5 / Rasl10b / Ras-like protein family member 10B / Q96S79* / RAS like family 10 member B*ENSMUSG0000002068421
Gm266ENSMUSG0000001052918


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
Show

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Rhebtm1.1Otsu/Rhebtm1.1Otsu,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Rhebtm1.1Otsu/Rhebtm1.1Otsu,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0020474 advanced circadian behavior phase "increase in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
Show

Allelic Composition: Oprk1tm1Kff/Oprk1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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