ENSMUSG00000037017


Mus musculus

Features
Gene ID: ENSMUSG00000037017
  
Biological name :Zscan21
  
Synonyms : Q07231 / zinc finger and SCAN domain containing 21 / Zscan21
  
Possible biological names infered from orthology : Q9Y5A6
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 138116903
Gene end: 138134265
  
Corresponding Affymetrix probe sets: 10526735 (MoGene1.0st)   1416370_at (Mouse Genome 430 2.0 Array)   1420095_s_at (Mouse Genome 430 2.0 Array)   1420096_at (Mouse Genome 430 2.0 Array)   1449732_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119570
Ensembl peptide - ENSMUSP00000121495
Ensembl peptide - ENSMUSP00000053430
Ensembl peptide - ENSMUSP00000079557
Ensembl peptide - ENSMUSP00000106584
Ensembl peptide - ENSMUSP00000106585
Ensembl peptide - ENSMUSP00000106586
NCBI entrez gene - 22697     See in Manteia.
MGI - MGI:99182
RefSeq - NM_011757
RefSeq - XM_011240942
RefSeq - NM_001044703
RefSeq - NM_001044704
RefSeq - NM_001044705
RefSeq Peptide - NP_001038168
RefSeq Peptide - NP_001038169
RefSeq Peptide - NP_001038170
RefSeq Peptide - NP_035887
swissprot - F6QX94
swissprot - D3Z1X7
swissprot - Q07231
Ensembl - ENSMUSG00000037017
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9Y5A6ENSG00000166529Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BGS3 / Zkscan1 / zinc finger with KRAB and SCAN domains 1 / P17029*ENSMUSG0000002972936
Zfp397 / zinc finger protein 397 / Q8NF99* / ZNF397*ENSMUSG0000002427636
Zkscan3 / zinc finger with KRAB and SCAN domains 3 / Q9BRR0* / Q969J2* / ZKSCAN4* / zinc finger with KRAB and SCAN domains 4*ENSMUSG0000002132735
Zkscan4 / zinc finger with KRAB and SCAN domains 4 / Q969J2* / Q9BRR0* / ZKSCAN3* / zinc finger with KRAB and SCAN domains 3*ENSMUSG0000005493135
Zkscan8 / zinc finger with KRAB and SCAN domains 8 / Q15776*ENSMUSG0000006389435
Q9Z1D7 / Zscan12 / zinc finger and SCAN domain containing 12 / O43309*ENSMUSG0000003672134
Zscan22 / zinc finger and SCAN domain containing 22 / P10073*ENSMUSG0000005471530
Zfp24 / Q91VN1 / zinc finger protein 24 / ZNF24* / P17028*ENSMUSG0000005146928
Q5RJ54 / Zscan26 / zinc finger and SCAN domain containing 26 / Q16670*ENSMUSG0000002222827


Protein motifs (from Interpro)
Interpro ID Name
 IPR003309  SCAN domain
 IPR008916  Retrovirus capsid, C-terminal
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048477 oogenesis IEA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Yes1tm2Sor/Yes1tm2Sor
Genetic Background: either: 129S7/SvEvBrd-Yes1tm2Sor or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0011751 abnormal X-Y chromosome synapsis during male meiosis "an anomaly in the process in which the side by side pairing and physical juxtaposition of X and Y chromosomes is created at the metaphase plate, usually resulting in incorrect sex chromosome disjunction" [MGI:llw2]
Show

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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