ENSMUSG00000051469


Mus musculus

Features
Gene ID: ENSMUSG00000051469
  
Biological name :Zfp24
  
Synonyms : Q91VN1 / Zfp24 / zinc finger protein 24
  
Possible biological names infered from orthology : P17028 / ZNF24
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A2
Gene start: 24009702
Gene end: 24020810
  
Corresponding Affymetrix probe sets: 10457844 (MoGene1.0st)   1422810_at (Mouse Genome 430 2.0 Array)   1426895_at (Mouse Genome 430 2.0 Array)   1426896_at (Mouse Genome 430 2.0 Array)   1430650_at (Mouse Genome 430 2.0 Array)   1430651_s_at (Mouse Genome 430 2.0 Array)   1450762_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064637
Ensembl peptide - ENSMUSP00000114282
Ensembl peptide - ENSMUSP00000122579
NCBI entrez gene - 59057     See in Manteia.
MGI - MGI:1929704
RefSeq - XM_006526137
RefSeq - NM_001357447
RefSeq - NM_001357448
RefSeq - NM_021559
RefSeq - XM_006526136
RefSeq Peptide - NP_001344377
RefSeq Peptide - NP_067534
RefSeq Peptide - NP_001344376
swissprot - Q91VN1
swissprot - D3YVP1
Ensembl - ENSMUSG00000051469
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ZNF24ENSG00000172466Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BGS3 / Zkscan1 / zinc finger with KRAB and SCAN domains 1 / P17029*ENSMUSG0000002972946
Zkscan8 / zinc finger with KRAB and SCAN domains 8 / Q15776*ENSMUSG0000006389446
Zfp397 / zinc finger protein 397 / Q8NF99* / ZNF397*ENSMUSG0000002427644
Q07231 / Zscan21 / zinc finger and SCAN domain containing 21 / Q9Y5A6*ENSMUSG0000003701742
Zkscan3 / zinc finger with KRAB and SCAN domains 3 / Q9BRR0* / Q969J2* / ZKSCAN4* / zinc finger with KRAB and SCAN domains 4*ENSMUSG0000002132742
Zkscan4 / zinc finger with KRAB and SCAN domains 4 / Q969J2* / Q9BRR0* / ZKSCAN3* / zinc finger with KRAB and SCAN domains 3*ENSMUSG0000005493140
Zscan22 / zinc finger and SCAN domain containing 22 / P10073*ENSMUSG0000005471538
Q5RJ54 / Zscan26 / zinc finger and SCAN domain containing 26 / Q16670*ENSMUSG0000002222837
Q9Z1D7 / Zscan12 / zinc finger and SCAN domain containing 12 / O43309*ENSMUSG0000003672137


Protein motifs (from Interpro)
Interpro ID Name
 IPR003309  SCAN domain
 IPR008916  Retrovirus capsid, C-terminal
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0042552 myelination IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: 129S/Sv-Drd2tm1Low

Allelic Composition: Zfp24hmcns/Zfp24tm1.2Pop
Genetic Background: involves: 129S4/SvJae * C3H/HeJ * C57BL/6

Allelic Composition: Zfp24tm1.2Pop/Zfp24tm1.2Pop
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Zfp24tm1.1Pop/Zfp24tm1.1Pop,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Zfp24hmcns-2J/Zfp24hmcns-2J
Genetic Background: CByJ(Cg)-Zfp24hmcns-2J/GrsrJ

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: 129S/Sv-Drd2tm1Low

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zfp24tm1.2Pop/Zfp24tm1.2Pop
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Zfp24hmcns-2J/Zfp24hmcns-2J
Genetic Background: CByJ(Cg)-Zfp24hmcns-2J/GrsrJ

 MP:0000956 reduced spinal cord size "smaller appearance of the spinal cord" [J:35802]
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Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: 129S/Sv-Drd2tm1Low

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: 129S/Sv-Drd2tm1Low

Allelic Composition: Zfp24tm1.2Pop/Zfp24tm1.2Pop
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Zfp24hmcns-2J/Zfp24hmcns-2J
Genetic Background: CByJ(Cg)-Zfp24hmcns-2J/GrsrJ

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: 129S/Sv-Drd2tm1Low

Allelic Composition: Zfp24tm1.2Pop/Zfp24tm1.2Pop
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Zfp24tm1.1Pop/Zfp24tm1.1Pop,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Zfp24hmcns-2J/Zfp24hmcns-2J
Genetic Background: CByJ(Cg)-Zfp24hmcns-2J/GrsrJ

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: 129S/Sv-Drd2tm1Low

Allelic Composition: Zfp24hmcns/Zfp24tm1.2Pop
Genetic Background: involves: 129S4/SvJae * C3H/HeJ * C57BL/6

Allelic Composition: Zfp24tm1.2Pop/Zfp24tm1.2Pop
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Zfp24tm1.1Pop/Zfp24tm1.1Pop,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004264 abnormal extraembryonic tissue physiology "functional anomaly of the membranes involved with embryonic protection and nutrition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbc1d20bs/Tbc1d20bs
Genetic Background: 129S;AKR-Tbc1d20bs/J

 MP:0004965 inner cell mass degeneration 
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Allelic Composition: Tbc1d20bs/Tbc1d20bs
Genetic Background: 129S;AKR-Tbc1d20bs/J

 MP:0008027 abnormal spinal cord white matter morphology "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: 129S/Sv-Drd2tm1Low

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd2tm1Low/Drd2+
Genetic Background: 129S/Sv-Drd2tm1Low

Allelic Composition: Zfp24tm1.2Pop/Zfp24tm1.2Pop
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Tbc1d20bs/Tbc1d20bs
Genetic Background: 129S;AKR-Tbc1d20bs/J

 MP:0011731 decreased myelin sheath thickness "decrease in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]
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Allelic Composition: Zfp24hmcns-2J/Zfp24hmcns-2J
Genetic Background: CByJ(Cg)-Zfp24hmcns-2J/GrsrJ

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Zfp24hmcns-2J/Zfp24hmcns-2J
Genetic Background: CByJ(Cg)-Zfp24hmcns-2J/GrsrJ

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Tbc1d20bs/Tbc1d20bs
Genetic Background: 129S;AKR-Tbc1d20bs/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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