Manteia - Molecule gene

ENSMUSG00000038301

Mus musculus

Features

Gene ID:	ENSMUSG00000038301

Biological name :	Snx10

Synonyms :	Q9CWT3 / Snx10 / sorting nexin 10

Possible biological names infered from orthology :	Q9Y5X0

Species:	Mus musculus

Chr. number:	6
Strand:	1
Band:	B3
Gene start:	51523901
Gene end:	51590679

Corresponding Affymetrix probe sets:	10538290 (MoGene1.0st) 1431055_a_at (Mouse Genome 430 2.0 Array) 1459764_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000136974 Ensembl peptide - ENSMUSP00000122639 Ensembl peptide - ENSMUSP00000138139 Ensembl peptide - ENSMUSP00000044165 Ensembl peptide - ENSMUSP00000110082 Ensembl peptide - ENSMUSP00000117914 NCBI entrez gene - 71982 See in Manteia. MGI - MGI:1919232 RefSeq - XM_017321753 RefSeq - NM_001127348 RefSeq - NM_001127349 RefSeq - NM_028035 RefSeq - XM_006506653 RefSeq - XM_011241474 RefSeq - XM_011241475 RefSeq Peptide - NP_082311 RefSeq Peptide - NP_001120820 RefSeq Peptide - NP_001120821 swissprot - Q9CWT3 swissprot - S4R1A0 swissprot - D3YW62 swissprot - Q4FJX6 swissprot - D3Z4P6 Ensembl - ENSMUSG00000038301

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
A8WG21	ENSDARG00000040474	Danio rerio
F1Q506	ENSDARG00000004405	Danio rerio
SNX10	ENSGALG00000011046	Gallus gallus
SNX10	ENSG00000086300	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Snx11 / Q91WL6 / Sorting nexin-11 / Q9Y5W9*	ENSMUSG00000020876	47
Snx3 / sorting nexin 3 / O60493*	ENSMUSG00000019804	20
Snx12 / sorting nexin 12 / Q9UMY4*	ENSMUSG00000046032	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR001683	Phox homologous domain
IPR036871	PX domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006897	endocytosis	IBA
biological_process	GO:0007032	endosome organization	ISS
biological_process	GO:0015031	protein transport	IEA
biological_process	GO:0016050	vesicle organization	IBA
biological_process	GO:0030030	cell projection organization	IEA
biological_process	GO:0030316	osteoclast differentiation	IMP
biological_process	GO:0060271	cilium assembly	ISO
biological_process	GO:0061512	protein localization to cilium	ISS
biological_process	GO:0071539	protein localization to centrosome	ISS
biological_process	GO:1990830	cellular response to leukemia inhibitory factor	IEP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005768	endosome	IBA
cellular_component	GO:0005783	endoplasmic reticulum	ISO
cellular_component	GO:0005813	centrosome	ISS
cellular_component	GO:0005815	microtubule organizing center	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0010008	endosome membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0019898	extrinsic component of membrane	IBA
cellular_component	GO:0031313	extrinsic component of endosome membrane	ISO
molecular_function	GO:0005545	1-phosphatidylinositol binding	ISS
molecular_function	GO:0008289	lipid binding	IEA
molecular_function	GO:0035091	phosphatidylinositol binding	IBA
molecular_function	GO:0051117	ATPase binding	ISO

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000062	increased bone density	"increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Ctsk^tm1(cre)Ska/Ctsk⁺,Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba} Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0000067	osteopetrosis	"excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr Allelic Composition: Ctsk^tm1(cre)Ska/Ctsk⁺,Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba} Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0000121	failure of tooth eruption	"inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr Allelic Composition: Ctsk^tm1(cre)Ska/Ctsk⁺,Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba} Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0000133	abnormal long bone metaphysis morphology	"malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0000195	hypocalcemia	"subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0000470	abnormal stomach morphology	"malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0001541	abnormal osteoclast function	"reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr Allelic Composition: Ctsk^tm1(cre)Ska/Ctsk⁺,Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba} Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr Allelic Composition: Ctsk^tm1(cre)Ska/Ctsk⁺,Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba} Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0002904	increased circulating parathyroid hormone level	"greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0003116	rickets	"overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0003795	abnormal bone structure		Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0004139	abnormal parietal cell morphology	"malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0004140	abnormal chief cell morphology	"malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0004991	decreased bone strength	"reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0006395	abnormal epiphyseal plate morphology	"any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr Allelic Composition: Ctsk^tm1(cre)Ska/Ctsk⁺,Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba} Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0008006	increased stomach pH	"change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0009445	osteomalacia	"gradual softening and bending of the bones due to failure of osteoid tissue to calcify as a result of vitamin D deficiency or renal tubular dysfunction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0010868	increased bone trabecula number	"increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0010875	increased bone volume	"increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0010876	decreased bone volume	"reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ctsk^tm1(cre)Ska/Ctsk⁺,Snx10^{tm1c(EUCOMM)Raba}/Snx10^{tm1c(EUCOMM)Raba} Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
MP:0010926	increased osteoid volume	"increase in the amount of space occupied by newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0012336	decreased vitamin D level	"reduced level of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0013631	decreased bone trabecular spacing	"decrease in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr
MP:0013639	decreased bone stiffness	"decrease in material stiffness (N/mm) during elastic deformation" [MGI:jwhite]	Show Allelic Composition: Kdelr1^em1Btlr/Kdelr1^em1Btlr,Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr/0 Genetic Background: C57BL/6J-Kdelr1^em1Btlr Tg(Gt(ROSA)26Sor-Kdelr1)#Btlr

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr