ENSDARG00000104230


Danio rerio

Features
Gene ID: ENSDARG00000104230
  
Biological name :sec23a
  
Synonyms : Q7SZE5 / sec23a / Sec23 homolog A, COPII coat complex component
  
Possible biological names infered from orthology : Protein transport protein Sec23A / Q01405 / Q15436 / Sec23 homolog A, coat complex II component
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 10090638
Gene end: 10145432
  
Corresponding Affymetrix probe sets: Dr.5511.1.S1_at (Zebrafish Array)   NM_213465_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000137308
Ensembl peptide - ENSDARP00000139718
Ensembl peptide - ENSDARP00000134628
NCBI entrez gene - 406774     See in Manteia.
RefSeq - NM_213465
RefSeq Peptide - NP_998630
swissprot - B2GSV7
swissprot - Q7SZE5
ZFIN ID - ZDB-GENE-040426-2823
Ensembl - ENSDARG00000104230
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SEC23AENSGALG00000010150Gallus gallus
 Q15436ENSG00000100934Homo sapiens
 Q01405ENSMUSG00000020986Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sec23b / Sec23 homolog B, COPII coat complex component / Q9D662* / Q15437* / Sec23 homolog B, coat complex II component* / Mus musculus SEC23 homolog B, COPII coat complex component (Sec23b...ENSDARG0000001936082


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR006895  Zinc finger, Sec23/Sec24-type
 IPR006896  Sec23/Sec24, trunk domain
 IPR006900  Sec23/Sec24, helical domain
 IPR007123  Gelsolin-like domain
 IPR012990  Sec23/Sec24 beta-sandwich
 IPR029006  ADF-H/Gelsolin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035138 pectoral fin morphogenesis IMP
 biological_processGO:0048702 embryonic neurocranium morphogenesis IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0090110 cargo loading into COPII-coated vesicle ISS
 biological_processGO:0090114 COPII-coated vesicle budding IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane ISS
 cellular_componentGO:0030127 COPII vesicle coat ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0070971 endoplasmic reticulum exit site ISS
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
MHC class II antigen presentation
Cargo concentration in the ER
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000292 surface structure surface structure quality , abnormal
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 ZFA:0000431 semicircular canal semicircular canal aplastic , abnormal
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 ZFA:0000737 cranium cranium quality , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
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 ZFA:0001114 head head decreased length , abnormal
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 ZFA:0001161 pectoral fin pectoral fin quality , abnormal
pectoral fin decreased length , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019581 uso1 / USO1 vesicle transport factor / O60763* / Q9Z1Z0* / USO1 vesicle docking factor*  / reaction / complex
 ENSDARG00000006125 Q6P3K7 / csnk1db / casein kinase 1, delta b / Q9DC28* / CSNK1D* / P48730* / casein kinase 1 delta*  / reaction
 ENSDARG00000025033 stx5a / syntaxin 5A / STX5* / Q8K1E0* / Q13190* / syntaxin 5*  / complex / reaction
 ENSDARG00000008184 mia3 / melanoma inhibitory activity family, member 3 / Q5JRA6* / transport and Golgi organization * / MIA family member 3, ER export factor*  / reaction / complex
 ENSDARG00000009087 cd74a / CD74 molecule, major histocompatibility complex, class II invariant chain a / CD74* / P04233* / P04441* / CD74 molecule* / CD74 antigen (invariant polypeptide of major histocompatib...  / complex / reaction
 ENSDARG00000008370 Q7T2E3 / csnk1da / casein kinase 1, delta a / CSNK1D* / P48730* / casein kinase 1 delta*  / reaction
 ENSDARG00000029663 rab1ab / RAB1A, member RAS oncogene family b / Rab1* / RAB1A* / P62821* / P62820* / Ras-related protein Rab-1A * / RAB1A, member RAS oncogene family*  / complex / reaction
 ENSDARG00000054807 sec13 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735* / Q9D1M0*  / complex / reaction
 ENSDARG00000053070 gosr2 / golgi SNAP receptor complex member 2 / O14653* / O35166* / AC005670.2*  / complex / reaction
 ENSDARG00000021082 sec31a / SEC31 homolog A, COPII coat complex component / O94979* / Q3UPL0* / Protein transport protein Sec31A *  / complex / reaction
 ENSDARG00000071906 sec24b / SEC24 homolog B, COPII coat complex component / O95487* / Sec24 related gene family, member B (S. cerevisiae)*  / complex / reaction
 ENSDARG00000103516 sec24c / SEC24 homolog C, COPII coat complex component / P53992* / Sec24 related gene family, member C (S. cerevisiae)*  / complex / reaction
 ENSDARG00000100435 Q7SXP0 / sec22bb / SEC22 homolog B, vesicle trafficking protein b / SEC22B* / O08547* / O75396* / Vesicle-trafficking protein SEC22b * / SEC22 homolog B, vesicle trafficking protein (gene/p...  / complex / reaction
 ENSDARG00000003641 tfg / trk-fused gene / Q92734*  / complex
 ENSDARG00000053136 b2m / Q04475 / beta-2-microglobulin / P01887* / P61769*  / complex
 ENSDARG00000063197 golga2 / golgin A2 / A6NMD2* / A7E2F4* / A8MQT2* / A8MZA4* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* / Q08AF8* / Q8N9W4* / Q921M4* ...  / complex / reaction
 ENSDARG00000071168 zmp:0000001138 / B2M* / P61769* / beta-2-microglobulin*  / complex
 ENSDARG00000015887 b2ml / beta-2-microglobulin, like / B2M* / P01887* / P61769* / beta-2-microglobulin*  / complex
 ENSDARG00000104375 sec24a / SEC24 homolog A, COPII coat complex component / O95486*  / complex / reaction
 ENSDARG00000103403 sar1b / secretion associated, Ras related GTPase 1B / Q9Y6B6*  / complex / reaction
 ENSDARG00000101602 preb / prolactin regulatory element binding / Q9HCU5* / Q9WUQ2*  / complex / reaction
 ENSDARG00000099554 sec16b / SEC16 homolog B, endoplasmic reticulum export factor / Q91XT4* / Q96JE7* / Protein transport protein Sec16B *  / complex






 

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