ENSDARG00000020890


Danio rerio

Features
Gene ID: ENSDARG00000020890
  
Biological name :tmod4
  
Synonyms : tmod4 / tropomodulin 4 (muscle)
  
Possible biological names infered from orthology : Q9JLH8 / Q9NZQ9 / tropomodulin 4
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 29650698
Gene end: 29684858
  
Corresponding Affymetrix probe sets: Dr.373.1.S1_at (Zebrafish Array)   NM_131196_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000112954
Ensembl peptide - ENSDARP00000152247
NCBI entrez gene - 30441     See in Manteia.
RefSeq - NM_131196
RefSeq Peptide - NP_571271
swissprot - Q9PUQ6
ZFIN ID - ZDB-GENE-991019-9
Ensembl - ENSDARG00000020890
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TMOD4ENSGALG00000030247Gallus gallus
 TMOD4ENSG00000163157Homo sapiens
 Tmod4ENSMUSG00000005628Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tmod1 / tropomodulin 1 / P28289* / P49813*ENSDARG0000007831861
tmod2 / tropomodulin 2 / TMOD3* / Q9NZR1* / Q9JHJ0* / Q9JKK7* / Q9NYL9* / tropomodulin 3*ENSDARG0000000257158
lmod3 / E7F7X0 / leiomodin 3 (fetal) / Q0VAK6* / E9QA62* / leiomodin 3*ENSDARG0000006266235
lmod2b / leiomodin 2 (cardiac) b / LMOD2* / Q3UHZ5* / Q6P5Q4* / leiomodin 2*ENSDARG0000004586435
lmod1a / leiomodin 1a (smooth muscle) / LMOD1* / P29536* / leiomodin 1*ENSDARG0000005611132
lmod2a / leiomodin 2 (cardiac) a / LMOD2* / Q3UHZ5* / Q6P5Q4* / leiomodin 2*ENSDARG0000004563429
lmod1b / leiomodin 1b (smooth muscle) / LMOD1* / P29536* / leiomodin 1*ENSDARG0000007726126


Protein motifs (from Interpro)
Interpro ID Name
 IPR004934  Tropomodulin
 IPR030129  Tropomodulin-4
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction IBA
 biological_processGO:0007015 actin filament organization IBA
 biological_processGO:0014866 skeletal myofibril assembly IMP
 biological_processGO:0051694 pointed-end actin filament capping IEA
 cellular_componentGO:0005865 striated muscle thin filament IBA
 molecular_functionGO:0005523 tropomyosin binding IBA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder absent , abnormal
Show

 ZFA:0001056 myotome myotome striated muscle thin filament disoriented , abnormal
myotome skeletal muscle myofibril malformed , abnormal
Show

 ZFA:0001216 splanchnocranium splanchnocranium malformed , abnormal
Show

 ZFA:0005277 skeletal muscle skeletal muscle decreased strength , abnormal
Show

 ZFA:0007052 hyohyoideus hyohyoideus misaligned away from hyohyoideus , abnormal
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 ZFA:0009117 fast muscle cell fast muscle cell myofibril malformed , abnormal
fast muscle cell striated muscle thin filament disorganized , abnormal
fast muscle cell striated muscle thin filament increased variability of size , abnormal
fast muscle cell sarcomere malformed , abnormal
fast muscle cell Z disc increased width , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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