ENSDARG00000026595


Danio rerio

Features
Gene ID: ENSDARG00000026595
  
Biological name :pafah1b1b
  
Synonyms : pafah1b1b / platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b
  
Possible biological names infered from orthology : P43034 / P63005 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 39423974
Gene end: 39454192
  
Corresponding Affymetrix probe sets: Dr.26364.1.A1_at (Zebrafish Array)   Dr.6616.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000039257
Ensembl peptide - ENSDARP00000149295
NCBI entrez gene - 394247     See in Manteia.
RefSeq - XM_021468786
swissprot - A0A0R4I9B2
ZFIN ID - ZDB-GENE-040116-3
Ensembl - ENSDARG00000026595
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9PTR5ENSGALG00000005834Gallus gallus
 P43034ENSG00000007168Homo sapiens
 P63005ENSMUSG00000020745Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7T394 / pafah1b1a / platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a / P43034* / P63005* / PAFAH1B1* / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1...ENSDARG0000003201394
nle1 / notchless homolog 1 (Drosophila) / Q8VEJ4* / Q9NVX2* / notchless homolog 1* / Notchless protein homolog 1 *ENSDARG0000005710526
wdr5 / WD repeat domain 5 / WDR5B* / Q9D7H2* / P61964* / P61965* / Q86VZ2* / WD repeat domain 5B*ENSDARG0000001690325
daw1 / dynein assembly factor with WDR repeat domains 1 / Q8N136* / dynein assembly factor with WD repeats 1*ENSDARG0000002146225
poc1b / A2CEH0 / POC1 centriolar protein B / Q8BHD1* / Q8TC44*ENSDARG0000002111021
katnb1 / Q7ZUV2 / katanin p80 (WD repeat containing) subunit B 1 / Q9BVA0* / Q8BG40* / katanin regulatory subunit B1* / Katanin p80 WD40 repeat-containing subunit B1 *ENSDARG0000000545620
snrnp40 / small nuclear ribonucleoprotein 40 (U5) / Q96DI7* / Q6PE01* / small nuclear ribonucleoprotein U5 subunit 40* / U5 small nuclear ribonucleoprotein 40 kDa protein *ENSDARG0000002316020
wdr38 / WD repeat domain 38 / Q5JTN6*ENSDARG0000004480112
poc1a / POC1 centriolar protein A / Q8JZX3* / Q8NBT0*ENSDARG0000007853312
wdr61 / WD repeat domain 61 / Q9ERF3* / Q9GZS3*ENSDARG0000000775511


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR006594  LIS1 homology motif
 IPR017252  Dynein regulator LIS1
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IEA
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005875 microtubule associated complex IEA
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
COPI-independent Golgi-to-ER retrograde traffic
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain decreased size , abnormal
brain cell necrotic , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
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 ZFA:0000050 optic vesicle optic vesicle malformed , abnormal
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 ZFA:0000077 tail bud tail bud decreased size , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart swollen , abnormal
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 ZFA:0000135 notochord notochord malformed , abnormal
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 ZFA:0000473 trunk musculature trunk musculature disorganized , abnormal
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 ZFA:0000706 posterior intestine posterior intestine morphology , abnormal
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 ZFA:0001094 whole organism whole organism curved ventral , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism movement quality , abnormal
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 ZFA:0009090 pigment cell pigment cell morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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