ENSGALG00000005834


Gallus gallus

Features
Gene ID: ENSGALG00000005834
  
Biological name :PAFAH1B1
  
Synonyms : Lissencephaly-1 homolog / PAFAH1B1 / Q9PTR5
  
Possible biological names infered from orthology : P43034 / P63005 / platelet activating factor acetylhydrolase 1b regulatory subunit 1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
  
Species: Gallus gallus
  
Chr. number: 19
Strand: 1
Band:
Gene start: 9462121
Gene end: 9491244
  
Corresponding Affymetrix probe sets: Gga.11892.1.S1_s_at (Chicken Array)   Gga.3126.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000064620
Ensembl peptide - ENSGALP00000009354
Ensembl peptide - ENSGALP00000046620
Ensembl peptide - ENSGALP00000052419
NCBI entrez gene - 374224     See in Manteia.
RefSeq - XM_015295661
RefSeq - NM_204324
RefSeq - XM_015295659
RefSeq - XM_015295660
RefSeq Peptide - NP_989655
swissprot - A0A1D5PHY8
swissprot - Q9PTR5
Ensembl - ENSGALG00000005834
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pafah1b1bENSDARG00000026595Danio rerio
 Q7T394ENSDARG00000032013Danio rerio
 P43034ENSG00000007168Homo sapiens
 P63005ENSMUSG00000020745Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DAW1 / dynein assembly factor with WD repeats 1 / Q8N136*ENSGALG0000000299226
WDR5 / WD repeat-containing protein 5 / WDR5B* / Q9D7H2* / P61964* / P61965* / Q86VZ2* / WD repeat domain 5* / WD repeat domain 5B*ENSGALG0000000265925
POC1A / POC1 centriolar protein A / Q8JZX3* / Q8NBT0*ENSGALG0000003457222
POC1B / POC1 centriolar protein homolog B / Q8BHD1* / Q8TC44* / POC1 centriolar protein B*ENSGALG0000003549322
SNRNP40 / U5 small nuclear ribonucleoprotein 40 kDa protein / Q6PE01* / Q96DI7* / small nuclear ribonucleoprotein U5 subunit 40*ENSGALG0000000061520
KATNB1 / Q5ZIU8 / Katanin p80 WD40 repeat-containing subunit B1 / Q9BVA0* / Q8BG40* / katanin regulatory subunit B1*ENSGALG0000003437319
WDR61 / WD repeat-containing protein 61 / Q9ERF3* / Q9GZS3* / WD repeat domain 61*ENSGALG0000000322115
NLE1* / Q8VEJ4* / Q9NVX2* / notchless homolog 1* / Notchless protein homolog 1 *ENSGALG0000000469114
NLE1* / Q8VEJ4* / Q9NVX2* / notchless homolog 1* / Notchless protein homolog 1 *ENSGALG0000003696311


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR006594  LIS1 homology motif
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017252  Dynein regulator LIS1
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IEA
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0001667 ameboidal-type cell migration IEA
 biological_processGO:0001675 acrosome assembly IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IEA
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007097 nuclear migration IBA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IBA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007405 neuroblast proliferation IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0008090 retrograde axonal transport IBA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0009306 protein secretion IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0019226 transmission of nerve impulse IEA
 biological_processGO:0021540 corpus callosum morphogenesis IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021819 layer formation in cerebral cortex IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0022008 neurogenesis IBA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031023 microtubule organizing center organization IBA
 biological_processGO:0036035 osteoclast development IEA
 biological_processGO:0040019 positive regulation of embryonic development IEA
 biological_processGO:0042249 establishment of planar polarity of embryonic epithelium IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043622 cortical microtubule organization IEA
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:0047496 vesicle transport along microtubule IBA
 biological_processGO:0048854 brain morphogenesis IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0051081 nuclear envelope disassembly IEA
 biological_processGO:0051130 positive regulation of cellular component organization IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051661 maintenance of centrosome location IEA
 biological_processGO:0060117 auditory receptor cell development IEA
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:0090176 microtubule cytoskeleton organization involved in establishment of planar polarity IEA
 biological_processGO:2000574 regulation of microtubule motor activity IBA
 cellular_componentGO:0000235 astral microtubule IEA
 cellular_componentGO:0000776 kinetochore IBA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IBA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005875 microtubule associated complex IEA
 cellular_componentGO:0005938 cell cortex IBA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0032420 stereocilium IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0008017 microtubule binding IBA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001547 P13127 / CAPZA1 / F-actin-capping protein subunit alpha-1 / P52907* / 4933400A11Rik* / RIKEN cDNA 4933400A11 gene* / capping actin protein of muscle Z-line alpha subunit 1*  / complex
 ENSGALG00000004034 CAPZB / P14315 / F-actin-capping protein subunit beta isoforms 1 and 2 / P47757* / P47756* / F-actin-capping protein subunit beta * / capping actin protein of muscle Z-line beta subunit*  / complex
 ENSGALG00000004534 DCTN4 / dynactin subunit 4 / Q8CBY8* / Q9UJW0* / Mus musculus dynactin 4 (Dctn4), transcript variant 2, mRNA.*  / complex
 ENSGALG00000008086 ACTR1A / ARP1 actin related protein 1 homolog A / P61163* / P61164* / Alpha-centractin *  / complex
 ENSGALG00000020999 DYNLL1 / dynein light chain LC8-type 1 / P63168* / P63167* / BC048507* / cDNA sequence BC048507* / Dynein light chain 1, cytoplasmic *  / complex
 ENSGALG00000005522 DYNLL2 / dynein light chain LC8-type 2 / Q96FJ2* / Q9D0M5* / Dynein light chain 2, cytoplasmic *  / complex
 ENSGALG00000006088 DCTN5 / dynactin subunit 5 / Q9BTE1* / Q9QZB9*  / complex
 ENSGALG00000005241 DYNC1LI2 / cytoplasmic dynein 1 light intermediate chain 2 / O43237* / Q6PDL0* / dynein cytoplasmic 1 light intermediate chain 2*  / complex
 ENSGALG00000017320 RAB6A / Q1KME6 / Ras-related protein Rab-6A / RAB6D* / RAB6C* / Q9H0N0* / P35279* / P20340* / RAB6A, member RAS oncogene family* / RAB6D, member RAS oncogene family* / RAB6C, member RAS on...  / reaction
 ENSGALG00000011106 GALNT2 / polypeptide N-acetylgalactosaminyltransferase 2 / Q6PB93* / Q10471* / Gm20388* / predicted gene 20388* / Polypeptide N-acetylgalactosaminyltransferase 2 Polypeptide N-acetylgalacto...  / reaction
 ENSGALG00000013135 GALNT1 / polypeptide N-acetylgalactosaminyltransferase 1 / O08912* / Q10472* / Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form*  / reaction
 ENSGALG00000011491 Q90828 / DYNC1LI1 / Cytoplasmic dynein 1 light intermediate chain 1 / Q8R1Q8* / Q9Y6G9* / dynein cytoplasmic 1 light intermediate chain 1*  / complex
 ENSGALG00000013125 CAPZA3 / capping actin protein of muscle Z-line alpha subunit 3 / P70190* / Q96KX2* / F-actin-capping protein subunit alpha-3 *  / complex
 ENSGALG00000021365 DCTN3 / dynactin subunit 3 / O75935* / Q9Z0Y1*  / complex
 ENSGALG00000010298 DCTN6 / dynactin subunit 6 / O00399* / Q9WUB4*  / complex
 ENSGALG00000043437 P28497 / CAPZA2 / F-actin-capping protein subunit alpha-2 / P47754* / P47755* / capping actin protein of muscle Z-line alpha subunit 2*  / complex
 ENSGALG00000011330 DYNC1H1 / dynein cytoplasmic 1 heavy chain 1 / Q14204* / Q9JHU4* / Cytoplasmic dynein 1 heavy chain 1 *  / complex






 

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