ENSDARG00000071560


Danio rerio

Features
Gene ID: ENSDARG00000071560
  
Biological name :dlx4b
  
Synonyms : distal-less homeobox 4b / dlx4b / Q98878
  
Possible biological names infered from orthology : distal-less homeobox 4 / DLX4 / Homeobox protein DLX-4 / P70436 / Q92988
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 5719616
Gene end: 5728755
  
Corresponding Affymetrix probe sets: Dr.153.1.S1_at (Zebrafish Array)   NM_131318_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000096665
NCBI entrez gene - 30581     See in Manteia.
RefSeq - NM_131318
RefSeq Peptide - NP_571393
swissprot - Q98878
ZFIN ID - ZDB-GENE-990415-50
Ensembl - ENSDARG00000071560
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DLX4ENSGALG00000045023Gallus gallus
 DLX4ENSG00000108813Homo sapiens
 Dlx4ENSMUSG00000020871Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dlx4a / Q98879 / distal-less homeobox 4a / DLX4* / P70436* / Q92988* / distal-less homeobox 4* / Homeobox protein DLX-4 *ENSDARG0000001195667
dlx6a / Q98877 / distal-less homeobox 6a / DLX6* / P56179* / P70397* / distal-less homeobox 6* / Homeobox protein DLX-6 *ENSDARG0000004229152
dlx1a / Q98875 / distal-less homeobox 1a / DLX1* / P56177* / distal-less homeobox 1*ENSDARG0000001312551
dlx2b / Q98876 / distal-less homeobox 2bENSDARG0000001717436
dlx5a / distal-less homeobox 5a / DLX5* / P70396* / P56178* / distal-less homeobox 5* / Homeobox protein DLX-5 *ENSDARG0000004229635
dlx2a / distal-less homeobox 2a / DLX2* / Q07687* / distal-less homeobox 2*ENSDARG0000007996435
dlx3b / distal-less homeobox 3b / DLX3* / Q64205* / O60479* / distal-less homeobox 3* / Homeobox protein DLX-3 *ENSDARG0000001462634
msx2b / Q01704 / muscle segment homeobox 2b / MSX2* / P35548* / msh homeobox 2*ENSDARG0000010102322
msx1a / muscle segment homeobox 1a / MSX1* / P28360* / msh homeobox 1*ENSDARG0000011611821
msx3 / muscle segment homeobox 3 / P70354* / Mus musculus msh homeobox 3 (Msx3), transcript variant 2, mRNA.*ENSDARG0000001567421
msx1b / Q03356 / muscle segment homeobox 1b / Msx3* / P70354* / Mus musculus msh homeobox 3 (Msx3), transcript variant 2, mRNA.*ENSDARG0000000888619
msx2a / muscle segment homeobox 2aENSDARG0000010465119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0021559 trigeminal nerve development IGI
 biological_processGO:0030910 olfactory placode formation IGI
 biological_processGO:0030916 otic vesicle formation IGI
 biological_processGO:0035270 endocrine system development IGI
 biological_processGO:0042667 auditory receptor cell fate specification IGI
 biological_processGO:0043010 camera-type eye development IGI
 biological_processGO:0043049 otic placode formation IGI
 biological_processGO:0048666 neuron development IGI
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0070306 lens fiber cell differentiation IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm increased size , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
otic vesicle inner ear receptor cell differentiation decreased process quality , abnormal
otic vesicle hair cell poorly differentiated , abnormal
otic vesicle morphology , abnormal
otic vesicle increased amount , abnormal
otic vesicle hypoplastic , abnormal
otic vesicle absent , abnormal
otic vesicle hair cell decreased amount , abnormal
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 ZFA:0000138 otic placode otic placode absent , abnormal
otic placode decreased distribution , abnormal
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 ZFA:0000217 inner ear inner ear lacks all parts of type otolith , abnormal
inner ear absent , abnormal
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 ZFA:0000250 opercle opercle fused with branchiostegal ray , abnormal
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 ZFA:0000281 hair cell posterior macula hair cell posterior macula absent , abnormal
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 ZFA:0000295 trigeminal ganglion trigeminal ganglion neuron decreased amount , abnormal
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 ZFA:0000678 hair cell anterior macula hair cell anterior macula absent , abnormal
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 ZFA:0001117 post-vent region post-vent region wholly ventralized , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage morphology , abnormal
Meckels cartilage decreased length , abnormal
Meckels cartilage tapered , abnormal
Meckels cartilage decreased distance ceratohyal cartilage , abnormal
Meckels cartilage decreased width , abnormal
Meckels cartilage deformed , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton joint absent , abnormal
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 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton joint absent , abnormal
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 ZFA:0001309 neurogenic placode neurogenic placode neuroblast increased amount , abnormal
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 ZFA:0001391 anterior lateral line ganglion anterior lateral line ganglion increased amount , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage morphology , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage increased angle to ceratohyal cartilage , abnormal
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 ZFA:0001580 neurocranium neurocranium morphology , abnormal
neurocranium decreased size , abnormal
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 ZFA:0001617 otolith otolith absent , abnormal
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 ZFA:0007068 otic epithelium otic epithelium decreased distribution , abnormal
otic epithelium absent , abnormal
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 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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