ENSG00000025423


Homo sapiens

Features
Gene ID: ENSG00000025423
  
Biological name :HSD17B6
  
Synonyms : HSD17B6 / hydroxysteroid 17-beta dehydrogenase 6 / O14756
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.3
Gene start: 56752161
Gene end: 56787790
  
Corresponding Affymetrix probe sets: 205700_at (Human Genome U133 Plus 2.0 Array)   37512_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452103
Ensembl peptide - ENSP00000451753
Ensembl peptide - ENSP00000452273
Ensembl peptide - ENSP00000318631
Ensembl peptide - ENSP00000450698
Ensembl peptide - ENSP00000451406
Ensembl peptide - ENSP00000451497
NCBI entrez gene - 8630     See in Manteia.
OMIM - 606623
RefSeq - XM_011538927
RefSeq - XM_005269208
RefSeq - XM_005269209
RefSeq - XM_006719672
RefSeq - XM_011538925
RefSeq - XM_011538926
RefSeq - NM_003725
RefSeq - XM_005269207
RefSeq Peptide - NP_003716
swissprot - G3V3Y9
swissprot - G3V508
swissprot - A0A024RB43
swissprot - O14756
Ensembl - ENSG00000025423
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9R092ENSMUSG00000025396Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RDH16 / O75452 / retinol dehydrogenase 16 (all-trans)ENSG0000013954766
RDH5 / Q92781 / retinol dehydrogenase 5ENSG0000013543750
Q8NEX9 / SDR9C7 / short chain dehydrogenase/reductase family 9C member 7ENSG0000017042650
DHRS9 / Q9BPW9 / dehydrogenase/reductase 9ENSG0000007373745
BDH1 / Q02338 / 3-hydroxybutyrate dehydrogenase 1ENSG0000016126736
P80365 / HSD11B2 / hydroxysteroid 11-beta dehydrogenase 2ENSG0000017638733
P37059 / HSD17B2 / hydroxysteroid 17-beta dehydrogenase 2ENSG0000008669633
P14061 / HSD17B1 / hydroxysteroid 17-beta dehydrogenase 1ENSG0000010878623
DHRS7 / Q9Y394 / dehydrogenase/reductase 7ENSG0000010061222
RDH8 / retinol dehydrogenase 8 (all-trans)ENSG0000008051121
DHRS7B / Q6IAN0 / dehydrogenase/reductase 7BENSG0000010901620
A6NNS2 / DHRS7C / dehydrogenase/reductase 7CENSG0000018454418
KDSR / Q06136 / 3-ketodihydrosphingosine reductaseENSG0000011953716


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006702 androgen biosynthetic process NAS
 biological_processGO:0006710 androgen catabolic process TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005622 intracellular NAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003824 catalytic activity TAS
 molecular_functionGO:0004303 estradiol 17-beta-dehydrogenase activity IEA
 molecular_functionGO:0004745 retinol dehydrogenase activity IEA
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity NAS
 molecular_functionGO:0047035 testosterone dehydrogenase (NAD+) activity IEA


Pathways (from Reactome)
Pathway description
The canonical retinoid cycle in rods (twilight vision)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr