ENSG00000108786


Homo sapiens

Features
Gene ID: ENSG00000108786
  
Biological name :HSD17B1
  
Synonyms : HSD17B1 / hydroxysteroid 17-beta dehydrogenase 1 / P14061
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.2
Gene start: 42549214
Gene end: 42555213
  
Corresponding Affymetrix probe sets: 205829_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000465128
Ensembl peptide - ENSP00000466799
Ensembl peptide - ENSP00000225929
NCBI entrez gene - 3292     See in Manteia.
OMIM - 109684
RefSeq - XM_011524732
RefSeq - XM_006721858
RefSeq - XM_006721859
RefSeq - XM_011524729
RefSeq - XM_011524730
RefSeq - XM_011524731
RefSeq - NM_000413
RefSeq - XM_005257292
RefSeq - XM_006721857
RefSeq Peptide - NP_000404
RefSeq Peptide - NP_001317148
swissprot - B4DU11
swissprot - A0A0A0MQS7
swissprot - P14061
Ensembl - ENSG00000108786
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsd17b1ENSDARG00000027469Danio rerio
 HSD17B1ENSGALG00000027429Gallus gallus
 P51656ENSMUSG00000019301Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RDH8 / retinol dehydrogenase 8 (all-trans)ENSG0000008051141
RDH16 / O75452 / retinol dehydrogenase 16 (all-trans)ENSG0000013954727
Q8NEX9 / SDR9C7 / short chain dehydrogenase/reductase family 9C member 7ENSG0000017042626
RDH5 / Q92781 / retinol dehydrogenase 5ENSG0000013543724
P80365 / HSD11B2 / hydroxysteroid 11-beta dehydrogenase 2ENSG0000017638722
BDH1 / Q02338 / 3-hydroxybutyrate dehydrogenase 1ENSG0000016126722
O14756 / HSD17B6 / hydroxysteroid 17-beta dehydrogenase 6ENSG0000002542322
DHRS7 / Q9Y394 / dehydrogenase/reductase 7ENSG0000010061221
DHRS9 / Q9BPW9 / dehydrogenase/reductase 9ENSG0000007373721
DHRS7B / Q6IAN0 / dehydrogenase/reductase 7BENSG0000010901620
A6NNS2 / DHRS7C / dehydrogenase/reductase 7CENSG0000018454419
P37059 / HSD17B2 / hydroxysteroid 17-beta dehydrogenase 2ENSG0000008669619
KDSR / Q06136 / 3-ketodihydrosphingosine reductaseENSG0000011953718


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR011348  17beta-dehydrogenase
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process TAS
 biological_processGO:0006703 estrogen biosynthetic process IEA
 biological_processGO:0008210 estrogen metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0061370 testosterone biosynthetic process IEA
 biological_processGO:0071248 cellular response to metal ion IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003824 catalytic activity TAS
 molecular_functionGO:0004303 estradiol 17-beta-dehydrogenase activity IEA
 molecular_functionGO:0005496 steroid binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0047035 testosterone dehydrogenase (NAD+) activity IEA
 molecular_functionGO:0070401 NADP+ binding IMP
 molecular_functionGO:1903924 estradiol binding IDA


Pathways (from Reactome)
Pathway description
Estrogen biosynthesis
The canonical retinoid cycle in rods (twilight vision)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108786 P14061 / HSD17B1 / hydroxysteroid 17-beta dehydrogenase 1  / complex






 

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