ENSG00000086696


Homo sapiens

Features
Gene ID: ENSG00000086696
  
Biological name :HSD17B2
  
Synonyms : HSD17B2 / hydroxysteroid 17-beta dehydrogenase 2 / P37059
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q23.3
Gene start: 82035004
Gene end: 82098534
  
Corresponding Affymetrix probe sets: 204818_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454931
Ensembl peptide - ENSP00000455992
Ensembl peptide - ENSP00000456471
Ensembl peptide - ENSP00000456529
Ensembl peptide - ENSP00000457943
Ensembl peptide - ENSP00000199936
NCBI entrez gene - 3294     See in Manteia.
OMIM - 109685
RefSeq - NM_002153
RefSeq Peptide - NP_002144
swissprot - P37059
swissprot - H3BNN1
swissprot - H3BQY3
swissprot - H3BRZ6
swissprot - H3BS44
swissprot - H3BV42
Ensembl - ENSG00000086696
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsd17b2ENSDARG00000045553Danio rerio
 HSD17B2ENSGALG00000005467Gallus gallus
 P51658ENSMUSG00000031844Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P80365 / HSD11B2 / hydroxysteroid 11-beta dehydrogenase 2ENSG0000017638738
BDH1 / Q02338 / 3-hydroxybutyrate dehydrogenase 1ENSG0000016126729
RDH16 / O75452 / retinol dehydrogenase 16 (all-trans)ENSG0000013954728
O14756 / HSD17B6 / hydroxysteroid 17-beta dehydrogenase 6ENSG0000002542327
Q8NEX9 / SDR9C7 / short chain dehydrogenase/reductase family 9C member 7ENSG0000017042626
RDH5 / Q92781 / retinol dehydrogenase 5ENSG0000013543725
DHRS9 / Q9BPW9 / dehydrogenase/reductase 9ENSG0000007373724
DHRS7B / Q6IAN0 / dehydrogenase/reductase 7BENSG0000010901617
DHRS7 / Q9Y394 / dehydrogenase/reductase 7ENSG0000010061217
P14061 / HSD17B1 / hydroxysteroid 17-beta dehydrogenase 1ENSG0000010878616
RDH8 / retinol dehydrogenase 8 (all-trans)ENSG0000008051116
A6NNS2 / DHRS7C / dehydrogenase/reductase 7CENSG0000018454413
KDSR / Q06136 / 3-ketodihydrosphingosine reductaseENSG0000011953712


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006703 estrogen biosynthetic process TAS
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004303 estradiol 17-beta-dehydrogenase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity TAS
 molecular_functionGO:0047035 testosterone dehydrogenase (NAD+) activity IEA


Pathways (from Reactome)
Pathway description
Estrogen biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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