ENSMUSG00000031844


Mus musculus

Features
Gene ID: ENSMUSG00000031844
  
Biological name :Hsd17b2
  
Synonyms : Hsd17b2 / hydroxysteroid (17-beta) dehydrogenase 2 / P51658
  
Possible biological names infered from orthology : P37059
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 117701904
Gene end: 117759027
  
Corresponding Affymetrix probe sets: 10575833 (MoGene1.0st)   1418352_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148323
Ensembl peptide - ENSMUSP00000034304
NCBI entrez gene - 15486     See in Manteia.
MGI - MGI:1096386
RefSeq - NM_008290
RefSeq - XM_006530703
RefSeq Peptide - NP_032316
swissprot - A0A1D5RLD6
swissprot - P51658
Ensembl - ENSMUSG00000031844
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsd17b2ENSDARG00000045553Danio rerio
 HSD17B2ENSGALG00000005467Gallus gallus
 P37059ENSG00000086696Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P51661 / Hsd11b2 / hydroxysteroid 11-beta dehydrogenase 2 / P80365*ENSMUSG0000003189138
Rdh1 / retinol dehydrogenase 1 (all trans) / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000008978931
Rdh19 / retinol dehydrogenase 19 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000005405231
Rdh16f1 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000009900931
Rdh9 / retinol dehydrogenase 9 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000005614831
Rdh16 / retinol dehydrogenase 16 / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000006945631
Rdh16f2 / RDH16 family member 2 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000007463930
Rdh7 / O88451 / Retinol dehydrogenase 7 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000004013429
Q9R092 / Hsd17b6 / Mus musculus hydroxysteroid (17-beta) dehydrogenase 6 (Hsd17b6), transcript variant 2, mRNA. / O14756* / hydroxysteroid 17-beta dehydrogenase 6*ENSMUSG0000002539629
Bdh1 / Q80XN0 / D-beta-hydroxybutyrate dehydrogenase, mitochondrial / Q02338* / 3-hydroxybutyrate dehydrogenase 1*ENSMUSG0000004659828
Q8K3P0 / Sdr9c7 / 4short chain dehydrogenase/reductase family 9C, member 7 / Q8NEX9* / short chain dehydrogenase/reductase family 9C member 7*ENSMUSG0000004012727
Dhrs9 / Q58NB6 / Dehydrogenase/reductase SDR family member 9 / Q9BPW9* / dehydrogenase/reductase 9*ENSMUSG0000002706826
Rdh5 / O55240 / Mus musculus retinol dehydrogenase 5 (Rdh5), transcript variant 2, mRNA. / Q92781* / retinol dehydrogenase 5*ENSMUSG0000002535026
Dhrs7b / Q99J47 / Dehydrogenase/reductase SDR family member 7B / Q6IAN0* / dehydrogenase/reductase 7B*ENSMUSG0000004256919
Rdh8 / retinol dehydrogenase 8 (all-trans)ENSMUSG0000005377319
Dhrs7 / Q9CXR1 / Dehydrogenase/reductase SDR family member 7 / Q9Y394* / dehydrogenase/reductase 7*ENSMUSG0000002109419
Gm4756ENSMUSG0000010948218
P51656 / Hsd17b1 / hydroxysteroid (17-beta) dehydrogenase 1 / P14061*ENSMUSG0000001930117
Dhrs7c / Q8CHS7 / Dehydrogenase/reductase SDR family member 7C / A6NNS2* / dehydrogenase/reductase 7C*ENSMUSG0000003304415
Kdsr / Q6GV12 / 3-ketodihydrosphingosine reductase / Q06136*ENSMUSG0000000990515


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004303 estradiol 17-beta-dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0047035 testosterone dehydrogenase (NAD+) activity ISO


Pathways (from Reactome)
Pathway description
Estrogen biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0003014 abnormal kidney medulla morphology "anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0009641 kidney degeneration "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0011408 renal tubule hypertrophy "increase in the bulk size of the loop of Henle, the proximal convoluted tubule or the distal convoluted tubule, due to cell enlargement" [MGI:anna]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0011527 disorganized placental labyrinth "derangement of the placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0011843 abnormal kidney collecting duct epithelium morphology "any structural anomaly of the simple cuboidal epithelium lining the lumen of kidney collecting ducts; the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" [MGI:anna]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0012098 increased spongiotrophoblast size "greater size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0020526 enlarged thalamus "increased size of the thalamus" [MGI:smb]
Show

Allelic Composition: Tyrp1rgsc101/Tyrp1rgsc101
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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