ENSMUSG00000025350


Mus musculus

Features
Gene ID: ENSMUSG00000025350
  
Biological name :Rdh5
  
Synonyms : Mus musculus retinol dehydrogenase 5 (Rdh5), transcript variant 2, mRNA. / O55240 / Rdh5
  
Possible biological names infered from orthology : Q92781 / retinol dehydrogenase 5
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 128913593
Gene end: 128922888
  
Corresponding Affymetrix probe sets: 10373588 (MoGene1.0st)   10373594 (MoGene1.0st)   10457924 (MoGene1.0st)   1418808_at (Mouse Genome 430 2.0 Array)   1422614_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116558
Ensembl peptide - ENSMUSP00000123358
Ensembl peptide - ENSMUSP00000123183
Ensembl peptide - ENSMUSP00000026406
Ensembl peptide - ENSMUSP00000115182
NCBI entrez gene - 19682     See in Manteia.
MGI - MGI:1201412
RefSeq - XM_006513385
RefSeq - XM_006513388
RefSeq - XM_006513387
RefSeq - XM_006513386
RefSeq - NM_001358527
RefSeq - NM_134006
RefSeq Peptide - NP_001345456
RefSeq Peptide - NP_598767
swissprot - O55240
swissprot - D3Z0N7
swissprot - D3YWG0
swissprot - F7CWI9
swissprot - D3YZQ7
Ensembl - ENSMUSG00000025350
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rdh5ENSDARG00000008306Danio rerio
 RDH5ENSG00000135437Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rdh1 / retinol dehydrogenase 1 (all trans) / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000008978952
Rdh9 / retinol dehydrogenase 9 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000005614851
Rdh16 / retinol dehydrogenase 16 / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000006945651
Rdh16f1 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000009900951
Rdh7 / O88451 / Retinol dehydrogenase 7 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000004013450
Rdh16f2 / RDH16 family member 2 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000007463949
Rdh19 / retinol dehydrogenase 19 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000005405249
Q8K3P0 / Sdr9c7 / 4short chain dehydrogenase/reductase family 9C, member 7 / Q8NEX9* / short chain dehydrogenase/reductase family 9C member 7*ENSMUSG0000004012747
Q9R092 / Hsd17b6 / Mus musculus hydroxysteroid (17-beta) dehydrogenase 6 (Hsd17b6), transcript variant 2, mRNA. / O14756* / hydroxysteroid 17-beta dehydrogenase 6*ENSMUSG0000002539646
Dhrs9 / Q58NB6 / Dehydrogenase/reductase SDR family member 9 / Q9BPW9* / dehydrogenase/reductase 9*ENSMUSG0000002706845
Bdh1 / Q80XN0 / D-beta-hydroxybutyrate dehydrogenase, mitochondrial / Q02338* / 3-hydroxybutyrate dehydrogenase 1*ENSMUSG0000004659834
P51661 / Hsd11b2 / hydroxysteroid 11-beta dehydrogenase 2 / P80365*ENSMUSG0000003189131
P51658 / Hsd17b2 / hydroxysteroid (17-beta) dehydrogenase 2 / P37059*ENSMUSG0000003184431
P51656 / Hsd17b1 / hydroxysteroid (17-beta) dehydrogenase 1 / P14061*ENSMUSG0000001930125
Rdh8 / retinol dehydrogenase 8 (all-trans)ENSMUSG0000005377324
Dhrs7b / Q99J47 / Dehydrogenase/reductase SDR family member 7B / Q6IAN0* / dehydrogenase/reductase 7B*ENSMUSG0000004256919
Gm4756ENSMUSG0000010948218
Dhrs7c / Q8CHS7 / Dehydrogenase/reductase SDR family member 7C / A6NNS2* / dehydrogenase/reductase 7C*ENSMUSG0000003304418
Dhrs7 / Q9CXR1 / Dehydrogenase/reductase SDR family member 7 / Q9Y394* / dehydrogenase/reductase 7*ENSMUSG0000002109417
Kdsr / Q6GV12 / 3-ketodihydrosphingosine reductase / Q06136*ENSMUSG0000000990516


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0044297 cell body IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
The canonical retinoid cycle in rods (twilight vision)
RA biosynthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003011 delayed dark adaptation "increase in time required for the eye to recover its sensitivity in the dark following exposure to bright lights" [J:68444, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rdh5tm1Drie/Rdh5tm1Drie
Genetic Background: Not Specified

Allelic Composition: Rdh5tm1Wsb/Rdh5tm1Wsb
Genetic Background: involves: 129 * C57BL/6J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rdh5tm1Wsb/Rdh5tm1Wsb
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039194 Rlbp1 / Q9Z275 / retinaldehyde binding protein 1 / P12271*  / reaction






 

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