ENSMUSG00000031891


Mus musculus

Features
Gene ID: ENSMUSG00000031891
  
Biological name :Hsd11b2
  
Synonyms : Hsd11b2 / hydroxysteroid 11-beta dehydrogenase 2 / P51661
  
Possible biological names infered from orthology : P80365
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 105518755
Gene end: 105523988
  
Corresponding Affymetrix probe sets: 10574780 (MoGene1.0st)   1416761_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034363
NCBI entrez gene - 15484     See in Manteia.
MGI - MGI:104720
RefSeq - NM_008289
RefSeq Peptide - NP_032315
swissprot - P51661
Ensembl - ENSMUSG00000031891
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsd11b2ENSDARG00000001975Danio rerio
 HSD11B2ENSGALG00000028326Gallus gallus
 P80365ENSG00000176387Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P51658 / Hsd17b2 / hydroxysteroid (17-beta) dehydrogenase 2 / P37059*ENSMUSG0000003184437
Rdh16 / retinol dehydrogenase 16 / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000006945629
Rdh16f1 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000009900929
Rdh9 / retinol dehydrogenase 9 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000005614829
Rdh19 / retinol dehydrogenase 19 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000005405228
Rdh16f2 / RDH16 family member 2 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000007463928
Rdh1 / retinol dehydrogenase 1 (all trans) / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000008978928
Rdh7 / O88451 / Retinol dehydrogenase 7 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*ENSMUSG0000004013427
Q9R092 / Hsd17b6 / Mus musculus hydroxysteroid (17-beta) dehydrogenase 6 (Hsd17b6), transcript variant 2, mRNA. / O14756* / hydroxysteroid 17-beta dehydrogenase 6*ENSMUSG0000002539627
Dhrs9 / Q58NB6 / Dehydrogenase/reductase SDR family member 9 / Q9BPW9* / dehydrogenase/reductase 9*ENSMUSG0000002706826
Bdh1 / Q80XN0 / D-beta-hydroxybutyrate dehydrogenase, mitochondrial / Q02338* / 3-hydroxybutyrate dehydrogenase 1*ENSMUSG0000004659825
Q8K3P0 / Sdr9c7 / 4short chain dehydrogenase/reductase family 9C, member 7 / Q8NEX9* / short chain dehydrogenase/reductase family 9C member 7*ENSMUSG0000004012725
Rdh5 / O55240 / Mus musculus retinol dehydrogenase 5 (Rdh5), transcript variant 2, mRNA. / Q92781* / retinol dehydrogenase 5*ENSMUSG0000002535025
Rdh8 / retinol dehydrogenase 8 (all-trans)ENSMUSG0000005377318
Gm4756ENSMUSG0000010948217
P51656 / Hsd17b1 / hydroxysteroid (17-beta) dehydrogenase 1 / P14061*ENSMUSG0000001930117
Dhrs7 / Q9CXR1 / Dehydrogenase/reductase SDR family member 7 / Q9Y394* / dehydrogenase/reductase 7*ENSMUSG0000002109417
Dhrs7b / Q99J47 / Dehydrogenase/reductase SDR family member 7B / Q6IAN0* / dehydrogenase/reductase 7B*ENSMUSG0000004256916
Dhrs7c / Q8CHS7 / Dehydrogenase/reductase SDR family member 7C / A6NNS2* / dehydrogenase/reductase 7C*ENSMUSG0000003304415
Kdsr / Q6GV12 / 3-ketodihydrosphingosine reductase / Q06136*ENSMUSG0000000990514


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR020904  Short-chain dehydrogenase/reductase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002017 regulation of blood volume by renal aldosterone IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0008211 glucocorticoid metabolic process IEA
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity IEA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Glucocorticoid biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikzf1tm1(Pax5)Mbu/Ikzf1tm1(Pax5)Mbu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Hsd11b2tm1.1Mzz/Hsd11b2tm1.1Mzz,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: ApcMin/Apc+,Hsd11b2tm1.1Mzz/Hsd11b2tm1.1Mzz,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0003963 abnormal corticosterone level "anomalous blood or tissue concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Hsd11b2tm1.1Mzz/Hsd11b2tm1.1Mzz,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0009051 dilated distal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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