Manteia

ENSMUSG00000019301

Mus musculus

Features

Gene ID:	ENSMUSG00000019301

Biological name :	Hsd17b1

Synonyms :	Hsd17b1 / hydroxysteroid (17-beta) dehydrogenase 1 / P51656

Possible biological names infered from orthology :	P14061

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	D
Gene start:	101078411
Gene end:	101080527

Corresponding Affymetrix probe sets:	10381218 (MoGene1.0st) 1449392_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000019445 NCBI entrez gene - 15485 See in Manteia. MGI - MGI:105077 RefSeq - XM_006532297 RefSeq - NM_010475 RefSeq Peptide - NP_034605 swissprot - P51656 swissprot - Q790P4 Ensembl - ENSMUSG00000019301

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
hsd17b1	ENSDARG00000027469	Danio rerio
HSD17B1	ENSGALG00000027429	Gallus gallus
P14061	ENSG00000108786	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Rdh8 / retinol dehydrogenase 8 (all-trans)	ENSMUSG00000053773	34
Rdh16f1 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*	ENSMUSG00000099009	24
Q8K3P0 / Sdr9c7 / 4short chain dehydrogenase/reductase family 9C, member 7 / Q8NEX9* / short chain dehydrogenase/reductase family 9C member 7*	ENSMUSG00000040127	24
Rdh1 / retinol dehydrogenase 1 (all trans) / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*	ENSMUSG00000089789	24
Rdh9 / retinol dehydrogenase 9 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*	ENSMUSG00000056148	24
Rdh16 / retinol dehydrogenase 16 / O75452* / retinol dehydrogenase 16 (all-trans)*	ENSMUSG00000069456	24
Rdh16f2 / RDH16 family member 2 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*	ENSMUSG00000074639	24
Rdh5 / O55240 / Mus musculus retinol dehydrogenase 5 (Rdh5), transcript variant 2, mRNA. / Q92781* / retinol dehydrogenase 5*	ENSMUSG00000025350	23
Rdh19 / retinol dehydrogenase 19 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*	ENSMUSG00000054052	23
Rdh7 / O88451 / Retinol dehydrogenase 7 / RDH16* / O75452* / retinol dehydrogenase 16 (all-trans)*	ENSMUSG00000040134	22
Bdh1 / Q80XN0 / D-beta-hydroxybutyrate dehydrogenase, mitochondrial / Q02338* / 3-hydroxybutyrate dehydrogenase 1*	ENSMUSG00000046598	21
Dhrs9 / Q58NB6 / Dehydrogenase/reductase SDR family member 9 / Q9BPW9* / dehydrogenase/reductase 9*	ENSMUSG00000027068	19
Gm4756	ENSMUSG00000109482	19
Q9R092 / Hsd17b6 / Mus musculus hydroxysteroid (17-beta) dehydrogenase 6 (Hsd17b6), transcript variant 2, mRNA. / O14756* / hydroxysteroid 17-beta dehydrogenase 6*	ENSMUSG00000025396	19
P51661 / Hsd11b2 / hydroxysteroid 11-beta dehydrogenase 2 / P80365*	ENSMUSG00000031891	19
P51658 / Hsd17b2 / hydroxysteroid (17-beta) dehydrogenase 2 / P37059*	ENSMUSG00000031844	19
Dhrs7b / Q99J47 / Dehydrogenase/reductase SDR family member 7B / Q6IAN0* / dehydrogenase/reductase 7B*	ENSMUSG00000042569	19
Kdsr / Q6GV12 / 3-ketodihydrosphingosine reductase / Q06136*	ENSMUSG00000009905	17
Dhrs7 / Q9CXR1 / Dehydrogenase/reductase SDR family member 7 / Q9Y394* / dehydrogenase/reductase 7*	ENSMUSG00000021094	17
Dhrs7c / Q8CHS7 / Dehydrogenase/reductase SDR family member 7C / A6NNS2* / dehydrogenase/reductase 7C*	ENSMUSG00000033044	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR002347	Short-chain dehydrogenase/reductase SDR
IPR011348	17beta-dehydrogenase
IPR020904	Short-chain dehydrogenase/reductase, conserved site
IPR036291	NAD(P)-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0006694	steroid biosynthetic process	IEA
biological_process	GO:0006703	estrogen biosynthetic process	IEA
biological_process	GO:0055114	oxidation-reduction process	IEA
biological_process	GO:0060348	bone development	IEA
biological_process	GO:0061370	testosterone biosynthetic process	IEA
biological_process	GO:0071248	cellular response to metal ion	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
molecular_function	GO:0004303	estradiol 17-beta-dehydrogenase activity	ISO
molecular_function	GO:0005496	steroid binding	ISO
molecular_function	GO:0016491	oxidoreductase activity	IEA
molecular_function	GO:0047035	testosterone dehydrogenase (NAD+) activity	IEA
molecular_function	GO:0070401	NADP+ binding	ISO
molecular_function	GO:1903924	estradiol binding	ISO

Pathways (from Reactome)

Pathway description

Estrogen biosynthesis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Ttn^tm2.1Hgra/Ttn^tm2.1Hgra Genetic Background: B6J.Cg-Ttn^tm2.1Hgra
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0001417	decreased exploration in new environment	"less amount of time spent investigating a new location" [J:79870]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0001523	impaired righting response	"reduced ability or greater amount of time needed to recover from supine position" [J:25565]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Ttn^tm2.1Hgra/Ttn^tm2.1Hgra Genetic Background: B6J.Cg-Ttn^tm2.1Hgra
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ttn^tm2.1Hgra/Ttn^tm2.1Hgra Genetic Background: B6J.Cg-Ttn^tm2.1Hgra
MP:0002636	delayed vaginal opening	"the opening of the genital canal in a female occuring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ttn^tm2.1Hgra/Ttn^tm2.1Hgra Genetic Background: B6J.Cg-Ttn^tm2.1Hgra
MP:0002679	abnormal corpora lutea	"malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ttn^tm2.1Hgra/Ttn^tm2.1Hgra Genetic Background: B6J.Cg-Ttn^tm2.1Hgra
MP:0002680	decreased number of corpora lutea	"fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ttn^tm2.1Hgra/Ttn^tm2.1Hgra Genetic Background: B6J.Cg-Ttn^tm2.1Hgra
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0004855	increased ovary weight	"greater average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ttn^tm2.1Hgra/Ttn^tm2.1Hgra Genetic Background: B6J.Cg-Ttn^tm2.1Hgra
MP:0004903	abnormal uterus weight	"anomaly in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ttn^tm2.1Hgra/Ttn^tm2.1Hgra Genetic Background: B6J.Cg-Ttn^tm2.1Hgra
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0005103	abnormal retinal pigmentation	"anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0005133	increased luteinizing hormone level	"higher than normal levels of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ttn^tm2.1Hgra/Ttn^tm2.1Hgra Genetic Background: B6J.Cg-Ttn^tm2.1Hgra
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0005627	increased circulating potassium level	"greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0011275	abnormal behavioral response to light	"unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H
MP:0011384	abnormal progesterone level	"anomaly in the concentration of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy" [ISBN:0-683-40008-8]	Show Allelic Composition: Ttn^tm2.1Hgra/Ttn^tm2.1Hgra Genetic Background: B6J.Cg-Ttn^tm2.1Hgra
MP:0011396	abnormal sleep behavior	"any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]	Show Allelic Composition: Golga3^{tm1b(EUCOMM)Hmgu}/Golga3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Golga3^{tm1b(EUCOMM)Hmgu}/H

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000019301	P51656 / Hsd17b1 / hydroxysteroid (17-beta) dehydrogenase 1 / P14061*	/ complex

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr