ENSG00000115041


Homo sapiens

Features
Gene ID: ENSG00000115041
  
Biological name :KCNIP3
  
Synonyms : KCNIP3 / potassium voltage-gated channel interacting protein 3 / Q9Y2W7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q11.1
Gene start: 95297304
Gene end: 95386083
  
Corresponding Affymetrix probe sets: 1555694_a_at (Human Genome U133 Plus 2.0 Array)   1569355_at (Human Genome U133 Plus 2.0 Array)   228269_x_at (Human Genome U133 Plus 2.0 Array)   231774_at (Human Genome U133 Plus 2.0 Array)   233688_at (Human Genome U133 Plus 2.0 Array)   234198_at (Human Genome U133 Plus 2.0 Array)   234647_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295225
Ensembl peptide - ENSP00000417499
Ensembl peptide - ENSP00000354261
NCBI entrez gene - 30818     See in Manteia.
OMIM - 604662
RefSeq - NM_001034914
RefSeq - NM_013434
RefSeq Peptide - NP_001030086
RefSeq Peptide - NP_038462
swissprot - Q9Y2W7
swissprot - A0A024RE22
swissprot - A0A0A0MRH3
Ensembl - ENSG00000115041
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnip3bENSDARG00000017880Danio rerio
 Kcnip3ENSMUSG00000079056Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNIP2 / Q9NS61 / potassium voltage-gated channel interacting protein 2ENSG0000012004963
KCNIP4 / Q6PIL6 / potassium voltage-gated channel interacting protein 4ENSG0000018577462
KCNIP1 / Q9NZI2 / potassium voltage-gated channel interacting protein 1ENSG0000018213255
NCS1 / P62166 / neuronal calcium sensor 1ENSG0000010713033
HPCAL1 / P37235 / hippocalcin like 1ENSG0000011575630
NCALD / P61601 / neurocalcin deltaENSG0000010449029
VSNL1 / P62760 / visinin like 1ENSG0000016303229
HPCA / P84074 / hippocalcinENSG0000012190529
HPCAL4 / Q9UM19 / hippocalcin like 4ENSG0000011698328
RCVRN / P35243 / recoverinENSG0000010904726
GUCA1B / Q9UMX6 / guanylate cyclase activator 1BENSG0000011259923
GUCA1A / P43080 / guanylate cyclase activator 1AENSG0000004854520
GUCA1C / O95843 / guanylate cyclase activator 1CENSG0000013847219


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0072659 protein localization to plasma membrane ISS
 biological_processGO:1901379 regulation of potassium ion transmembrane transport ISS
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0043679 axon terminus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015459 potassium channel regulator activity ISS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Phase 1 - inactivation of fast Na+ channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000182132 KCNIP1 / Q9NZI2 / potassium voltage-gated channel interacting protein 1  / complex
 ENSG00000184408 KCND2 / Q9NZV8 / potassium voltage-gated channel subfamily D member 2  / complex
 ENSG00000185774 KCNIP4 / Q6PIL6 / potassium voltage-gated channel interacting protein 4  / complex
 ENSG00000171385 KCND3 / Q9UK17 / potassium voltage-gated channel subfamily D member 3  / complex
 ENSG00000102057 KCND1 / Q9NSA2 / potassium voltage-gated channel subfamily D member 1  / complex
 ENSG00000115041 KCNIP3 / Q9Y2W7 / potassium voltage-gated channel interacting protein 3  / complex
 ENSG00000120049 KCNIP2 / Q9NS61 / potassium voltage-gated channel interacting protein 2  / complex






 

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