ENSG00000102057


Homo sapiens

Features
Gene ID: ENSG00000102057
  
Biological name :KCND1
  
Synonyms : KCND1 / potassium voltage-gated channel subfamily D member 1 / Q9NSA2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: p11.23
Gene start: 48961378
Gene end: 48971569
  
Corresponding Affymetrix probe sets: 206842_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000218176
Ensembl peptide - ENSP00000365660
Ensembl peptide - ENSP00000413989
NCBI entrez gene - 3750     See in Manteia.
OMIM - 300281
RefSeq - XM_017029509
RefSeq - NM_004979
RefSeq - XM_011543910
RefSeq - XM_017029508
RefSeq Peptide - NP_004970
swissprot - H7C3V4
swissprot - Q9NSA2
Ensembl - ENSG00000102057
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnd1ENSDARG00000074746Danio rerio
 Kcnd1ENSMUSG00000009731Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCND2 / Q9NZV8 / potassium voltage-gated channel subfamily D member 2ENSG0000018440866
KCND3 / Q9UK17 / potassium voltage-gated channel subfamily D member 3ENSG0000017138565
KCNA5 / P22460 / potassium voltage-gated channel subfamily A member 5ENSG0000013003728
KCNA7 / Q96RP8 / potassium voltage-gated channel subfamily A member 7ENSG0000010484827
KCNA3 / P22001 / potassium voltage-gated channel subfamily A member 3ENSG0000017727227
KCNA2 / P16389 / potassium voltage-gated channel subfamily A member 2ENSG0000017730127
KCNA4 / P22459 / potassium voltage-gated channel subfamily A member 4ENSG0000018225527
KCNC2 / Q96PR1 / potassium voltage-gated channel subfamily C member 2ENSG0000016600627
KCNC1 / P48547 / potassium voltage-gated channel subfamily C member 1ENSG0000012915926
KCNC4 / Q03721 / potassium voltage-gated channel subfamily C member 4ENSG0000011639626
KCNA1 / Q09470 / potassium voltage-gated channel subfamily A member 1ENSG0000011126226
KCNA6 / P17658 / potassium voltage-gated channel subfamily A member 6ENSG0000015107926
KCNC3 / Q14003 / potassium voltage-gated channel subfamily C member 3ENSG0000013139826
KCNA10 / Q16322 / potassium voltage-gated channel subfamily A member 10ENSG0000014310525


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR003131  Potassium channel tetramerisation-type BTB domain
 IPR003968  Potassium channel, voltage dependent, Kv
 IPR003975  Potassium channel, voltage dependent, Kv4
 IPR004054  Potassium channel, voltage dependent, Kv4.1
 IPR005821  Ion transport domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR021645  Shal-type voltage-gated potassium channels, N-terminal
 IPR024587  Potassium channel, voltage dependent, Kv4, C-terminal
 IPR028325  Voltage-gated potassium channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0005250 A-type (transient outward) potassium channel activity IBA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels
Phase 1 - inactivation of fast Na+ channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000184408 KCND2 / Q9NZV8 / potassium voltage-gated channel subfamily D member 2  / complex
 ENSG00000171385 KCND3 / Q9UK17 / potassium voltage-gated channel subfamily D member 3  / complex
 ENSG00000102057 KCND1 / Q9NSA2 / potassium voltage-gated channel subfamily D member 1  / complex
 ENSG00000120049 KCNIP2 / Q9NS61 / potassium voltage-gated channel interacting protein 2  / complex
 ENSG00000115041 KCNIP3 / Q9Y2W7 / potassium voltage-gated channel interacting protein 3  / complex
 ENSG00000182132 KCNIP1 / Q9NZI2 / potassium voltage-gated channel interacting protein 1  / complex
 ENSG00000185774 KCNIP4 / Q6PIL6 / potassium voltage-gated channel interacting protein 4  / complex






 

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