ENSG00000120049


Homo sapiens

Features
Gene ID: ENSG00000120049
  
Biological name :KCNIP2
  
Synonyms : KCNIP2 / potassium voltage-gated channel interacting protein 2 / Q9NS61
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.32
Gene start: 101825974
Gene end: 101843920
  
Corresponding Affymetrix probe sets: 1555230_a_at (Human Genome U133 Plus 2.0 Array)   221321_s_at (Human Genome U133 Plus 2.0 Array)   223727_at (Human Genome U133 Plus 2.0 Array)   224528_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420040
Ensembl peptide - ENSP00000411679
Ensembl peptide - ENSP00000495474
Ensembl peptide - ENSP00000239117
Ensembl peptide - ENSP00000239118
Ensembl peptide - ENSP00000341624
Ensembl peptide - ENSP00000344169
Ensembl peptide - ENSP00000349055
Ensembl peptide - ENSP00000350733
Ensembl peptide - ENSP00000359063
NCBI entrez gene - 30819     See in Manteia.
OMIM - 604661
RefSeq - XM_017016161
RefSeq - NM_014591
RefSeq - NM_173191
RefSeq - NM_173192
RefSeq - NM_173193
RefSeq - NM_173194
RefSeq - NM_173195
RefSeq - NM_173197
RefSeq - XM_005269729
RefSeq - XM_005269730
RefSeq - XM_006717812
RefSeq - XM_011539731
RefSeq Peptide - NP_775286
RefSeq Peptide - NP_775287
RefSeq Peptide - NP_775289
RefSeq Peptide - NP_775284
RefSeq Peptide - NP_775285
RefSeq Peptide - NP_055406
RefSeq Peptide - NP_775283
swissprot - Q9NS61
swissprot - A6NFF4
Ensembl - ENSG00000120049
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnip2ENSDARG00000075846Danio rerio
 KCNIP2ENSGALG00000007666Gallus gallus
 Kcnip2ENSMUSG00000025221Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNIP4 / Q6PIL6 / potassium voltage-gated channel interacting protein 4ENSG0000018577459
KCNIP3 / Q9Y2W7 / potassium voltage-gated channel interacting protein 3ENSG0000011504157
KCNIP1 / Q9NZI2 / potassium voltage-gated channel interacting protein 1ENSG0000018213250
NCS1 / P62166 / neuronal calcium sensor 1ENSG0000010713029
HPCAL4 / Q9UM19 / hippocalcin like 4ENSG0000011698328
HPCA / P84074 / hippocalcinENSG0000012190528
NCALD / P61601 / neurocalcin deltaENSG0000010449027
VSNL1 / P62760 / visinin like 1ENSG0000016303227
HPCAL1 / P37235 / hippocalcin like 1ENSG0000011575627
RCVRN / P35243 / recoverinENSG0000010904722
GUCA1B / Q9UMX6 / guanylate cyclase activator 1BENSG0000011259920
GUCA1A / P43080 / guanylate cyclase activator 1AENSG0000004854520
GUCA1C / O95843 / guanylate cyclase activator 1CENSG0000013847219


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005513 detection of calcium ion TAS
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport TAS
 biological_processGO:0006936 muscle contraction NAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0008016 regulation of heart contraction TAS
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0045163 clustering of voltage-gated potassium channels IDA
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0071435 potassium ion export IDA
 biological_processGO:0071805 potassium ion transmembrane transport IDA
 biological_processGO:0086009 membrane repolarization IDA
 biological_processGO:0086013 membrane repolarization during cardiac muscle cell action potential TAS
 biological_processGO:0097623 potassium ion export across plasma membrane TAS
 biological_processGO:1901379 regulation of potassium ion transmembrane transport ISS
 biological_processGO:2001257 regulation of cation channel activity TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008076 voltage-gated potassium channel complex NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0034705 potassium channel complex TAS
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005250 A-type (transient outward) potassium channel activity TAS
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015459 potassium channel regulator activity IDA
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046923 ER retention sequence binding NAS
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization TAS


Pathways (from Reactome)
Pathway description
Phase 1 - inactivation of fast Na+ channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000182132 KCNIP1 / Q9NZI2 / potassium voltage-gated channel interacting protein 1  / complex
 ENSG00000184408 KCND2 / Q9NZV8 / potassium voltage-gated channel subfamily D member 2  / complex
 ENSG00000185774 KCNIP4 / Q6PIL6 / potassium voltage-gated channel interacting protein 4  / complex
 ENSG00000102057 KCND1 / Q9NSA2 / potassium voltage-gated channel subfamily D member 1  / complex
 ENSG00000120049 KCNIP2 / Q9NS61 / potassium voltage-gated channel interacting protein 2  / complex
 ENSG00000171385 KCND3 / Q9UK17 / potassium voltage-gated channel subfamily D member 3  / complex
 ENSG00000115041 KCNIP3 / Q9Y2W7 / potassium voltage-gated channel interacting protein 3  / complex






 

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