ENSG00000185774


Homo sapiens

Features
Gene ID: ENSG00000185774
  
Biological name :KCNIP4
  
Synonyms : KCNIP4 / potassium voltage-gated channel interacting protein 4 / Q6PIL6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p15.2
Gene start: 20728616
Gene end: 21948799
  
Corresponding Affymetrix probe sets: 224530_s_at (Human Genome U133 Plus 2.0 Array)   236783_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000494651
Ensembl peptide - ENSP00000423257
Ensembl peptide - ENSP00000445321
Ensembl peptide - ENSP00000351892
Ensembl peptide - ENSP00000371583
Ensembl peptide - ENSP00000371585
Ensembl peptide - ENSP00000371587
Ensembl peptide - ENSP00000399080
NCBI entrez gene - 80333     See in Manteia.
OMIM - 608182
RefSeq - XM_017008653
RefSeq - NM_001035003
RefSeq - NM_001035004
RefSeq - NM_025221
RefSeq - NM_147181
RefSeq - NM_147182
RefSeq - NM_147183
RefSeq - XM_005248190
RefSeq - XM_011513882
RefSeq - XM_011513883
RefSeq - XM_011513884
RefSeq - XM_011513885
RefSeq - XM_011513886
RefSeq - XM_011513887
RefSeq - XM_011513889
RefSeq Peptide - NP_671712
RefSeq Peptide - NP_001030175
RefSeq Peptide - NP_001030176
RefSeq Peptide - NP_079497
RefSeq Peptide - NP_671710
RefSeq Peptide - NP_671711
swissprot - Q6PIL6
swissprot - Q3YAB7
swissprot - F5H395
Ensembl - ENSG00000185774
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KCNIP4ENSDARG00000088100Danio rerio
 si:ch211-145b13.5ENSDARG00000037256Danio rerio
 KCNIP4ENSGALG00000034621Gallus gallus
 Kcnip4ENSMUSG00000029088Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNIP2 / Q9NS61 / potassium voltage-gated channel interacting protein 2ENSG0000012004967
KCNIP3 / Q9Y2W7 / potassium voltage-gated channel interacting protein 3ENSG0000011504164
KCNIP1 / Q9NZI2 / potassium voltage-gated channel interacting protein 1ENSG0000018213261
NCS1 / P62166 / neuronal calcium sensor 1ENSG0000010713033
VSNL1 / P62760 / visinin like 1ENSG0000016303231
HPCAL4 / Q9UM19 / hippocalcin like 4ENSG0000011698329
HPCA / P84074 / hippocalcinENSG0000012190529
NCALD / P61601 / neurocalcin deltaENSG0000010449029
HPCAL1 / P37235 / hippocalcin like 1ENSG0000011575628
RCVRN / P35243 / recoverinENSG0000010904725
GUCA1B / Q9UMX6 / guanylate cyclase activator 1BENSG0000011259921
GUCA1A / P43080 / guanylate cyclase activator 1AENSG0000004854520
GUCA1C / O95843 / guanylate cyclase activator 1CENSG0000013847220


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0061337 cardiac conduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0072659 protein localization to plasma membrane ISS
 biological_processGO:1901379 regulation of potassium ion transmembrane transport ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015459 potassium channel regulator activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Phase 1 - inactivation of fast Na+ channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120049 KCNIP2 / Q9NS61 / potassium voltage-gated channel interacting protein 2  / complex
 ENSG00000115041 KCNIP3 / Q9Y2W7 / potassium voltage-gated channel interacting protein 3  / complex
 ENSG00000185774 KCNIP4 / Q6PIL6 / potassium voltage-gated channel interacting protein 4  / complex
 ENSG00000182132 KCNIP1 / Q9NZI2 / potassium voltage-gated channel interacting protein 1  / complex
 ENSG00000184408 KCND2 / Q9NZV8 / potassium voltage-gated channel subfamily D member 2  / complex
 ENSG00000171385 KCND3 / Q9UK17 / potassium voltage-gated channel subfamily D member 3  / complex
 ENSG00000102057 KCND1 / Q9NSA2 / potassium voltage-gated channel subfamily D member 1  / complex






 

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