ENSG00000166006


Homo sapiens

Features
Gene ID: ENSG00000166006
  
Biological name :KCNC2
  
Synonyms : KCNC2 / potassium voltage-gated channel subfamily C member 2 / Q96PR1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q21.1
Gene start: 75040077
Gene end: 75209868
  
Corresponding Affymetrix probe sets: 222289_at (Human Genome U133 Plus 2.0 Array)   240614_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438423
Ensembl peptide - ENSP00000376966
Ensembl peptide - ENSP00000448301
Ensembl peptide - ENSP00000449941
Ensembl peptide - ENSP00000449253
Ensembl peptide - ENSP00000298972
Ensembl peptide - ENSP00000319877
NCBI entrez gene - 3747     See in Manteia.
OMIM - 176256
RefSeq - XM_017019282
RefSeq - NM_001260498
RefSeq - NM_001260499
RefSeq - NM_139136
RefSeq - NM_139137
RefSeq - NM_153748
RefSeq - XM_005268855
RefSeq - XM_006719382
RefSeq - XM_006719383
RefSeq - XM_006719384
RefSeq - XM_006719385
RefSeq - NM_001260497
RefSeq Peptide - NP_001247427
RefSeq Peptide - NP_631874
RefSeq Peptide - NP_631875
RefSeq Peptide - NP_715624
RefSeq Peptide - NP_001247426
RefSeq Peptide - NP_001247428
swissprot - A0A024RBE3
swissprot - A0A024RBF2
swissprot - Q96PR1
swissprot - A0A024RBA5
Ensembl - ENSG00000166006
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnc2ENSDARG00000057468Danio rerio
 KCNC2ENSGALG00000010204Gallus gallus
 Kcnc2ENSMUSG00000035681Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNC4 / Q03721 / potassium voltage-gated channel subfamily C member 4ENSG0000011639665
KCNC1 / P48547 / potassium voltage-gated channel subfamily C member 1ENSG0000012915964
KCNC3 / Q14003 / potassium voltage-gated channel subfamily C member 3ENSG0000013139861
KCNA4 / P22459 / potassium voltage-gated channel subfamily A member 4ENSG0000018225529
KCNA2 / P16389 / potassium voltage-gated channel subfamily A member 2ENSG0000017730129
KCNA3 / P22001 / potassium voltage-gated channel subfamily A member 3ENSG0000017727229
KCNA7 / Q96RP8 / potassium voltage-gated channel subfamily A member 7ENSG0000010484828
KCNA5 / P22460 / potassium voltage-gated channel subfamily A member 5ENSG0000013003728
KCND1 / Q9NSA2 / potassium voltage-gated channel subfamily D member 1ENSG0000010205728
KCNA1 / Q09470 / potassium voltage-gated channel subfamily A member 1ENSG0000011126228
KCNA10 / Q16322 / potassium voltage-gated channel subfamily A member 10ENSG0000014310527
KCNA6 / P17658 / potassium voltage-gated channel subfamily A member 6ENSG0000015107927
KCND2 / Q9NZV8 / potassium voltage-gated channel subfamily D member 2ENSG0000018440826
KCND3 / Q9UK17 / potassium voltage-gated channel subfamily D member 3ENSG0000017138526


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR003131  Potassium channel tetramerisation-type BTB domain
 IPR003968  Potassium channel, voltage dependent, Kv
 IPR003974  Potassium channel, voltage dependent, Kv3
 IPR005821  Ion transport domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR028325  Voltage-gated potassium channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009642 response to light intensity IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0021759 globus pallidus development IEA
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0038060 nitric oxide-cGMP-mediated signaling pathway ISS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:0051291 protein heterooligomerization ISS
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071242 cellular response to ammonium ion IEA
 biological_processGO:0071732 cellular response to nitric oxide ISS
 biological_processGO:0071805 potassium ion transmembrane transport IBA
 biological_processGO:0097237 cellular response to toxic substance IEA
 biological_processGO:1901381 positive regulation of potassium ion transmembrane transport IEA
 biological_processGO:1903818 positive regulation of voltage-gated potassium channel activity IEA
 biological_processGO:1990089 response to nerve growth factor IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISS
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0016323 basolateral plasma membrane ISS
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030673 axolemma IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032809 neuronal cell body membrane ISS
 cellular_componentGO:0042734 presynaptic membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0045202 synapse ISS
 cellular_componentGO:0045211 postsynaptic membrane ISS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity ISS
 molecular_functionGO:0005251 delayed rectifier potassium channel activity ISS
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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