ENSG00000134317


Homo sapiens

Features
Gene ID: ENSG00000134317
  
Biological name :GRHL1
  
Synonyms : grainyhead like transcription factor 1 / GRHL1 / Q9NZI5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p25.1
Gene start: 9951693
Gene end: 10002277
  
Corresponding Affymetrix probe sets: 1552685_a_at (Human Genome U133 Plus 2.0 Array)   222830_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418275
Ensembl peptide - ENSP00000387521
Ensembl peptide - ENSP00000419831
Ensembl peptide - ENSP00000420654
Ensembl peptide - ENSP00000324693
Ensembl peptide - ENSP00000384209
NCBI entrez gene - 29841     See in Manteia.
OMIM - 609786
RefSeq - XM_017003901
RefSeq - XM_005246159
RefSeq - XM_006711882
RefSeq - XM_006711884
RefSeq - XM_011510343
RefSeq - XM_017003900
RefSeq - NM_198182
RefSeq Peptide - NP_937825
swissprot - C9JYY8
swissprot - F8WFB0
swissprot - B7Z1S6
swissprot - Q9NZI5
Ensembl - ENSG00000134317
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grhl1ENSDARG00000061391Danio rerio
 GRHL1ENSGALG00000038495Gallus gallus
 Grhl1ENSMUSG00000020656Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRHL2 / Q6ISB3 / grainyhead like transcription factor 2ENSG0000008330759
GRHL3 / Q8TE85 / grainyhead like transcription factor 3ENSG0000015805544
TFCP2 / Q12800 / transcription factor CP2ENSG0000013545720
Q9NZI6 / TFCP2L1 / transcription factor CP2 like 1ENSG0000011511219
UBP1 / Q9NZI7 / upstream binding protein 1ENSG0000015356019


Protein motifs (from Interpro)
Interpro ID Name
 IPR007604  CP2 transcription factor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002934 desmosome organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008544 epidermis development ISS
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0045616 regulation of keratinocyte differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0061436 establishment of skin barrier IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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